DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ste24a and zmpste24

DIOPT Version :9

Sequence 1:	NP_611175.1	Gene:	ste24a / 36908	FlyBaseID:	FBgn0034176	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_956186.1	Gene:	zmpste24 / 334380	ZFINID:	ZDB-GENE-030131-6312	Length:	468	Species:	Danio rerio

Alignment Length:	461	Identity:	218/461 - (47%)
Similarity:	308/461 - (66%)	Gaps:	24/461 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DTVLLSILFLVVIENALEIYISLRQVKVYQTALKVPAELKSHMGEDTFHKARKYGLDQEKFGIFK 71
            |.:..::||........|.|::.||.|:|:..:.||.||...|..:||.|:|.|.||:..||.:.
Zfish    12 DKIFYAVLFFSWTVYVWEAYLAYRQRKIYRATVHVPTELGKIMDSETFEKSRLYQLDKSNFGFWS 76

  Fly    72 AVVMDV--ALLCMELYIGLIAVLWQLSVQVVDKLQWDSKNEIIVSCVFVLISNVLSTFKGLPFKI 134
            .:..:.  .|:   |.:|.|..||:||..:.....:..:.||..|.||::::.:.|.|.|||:.:
Zfish    77 GLYSEFEGTLI---LLLGGIPFLWKLSGHLTAHFGFGPEYEISQSLVFLMLATLFSAFTGLPWSL 138

  Fly   135 YKIFVLEETHGFNKQTARFFAWDQLKGFLVTQVLMIPITAAIIFIVQRGGDNFFIWLWIFTGVIS 199
            |..||:||.||||:||..||..|.||.|.|||.:::|:|:.:::|::.|||.|||:.|:||.::|
Zfish   139 YNTFVIEEKHGFNQQTLGFFLKDALKKFAVTQCILVPVTSLLLYIIKIGGDYFFIYAWLFTFIVS 203

  Fly   200 LVLLTLYPIFIAPLFDKYTPLEKGALRQSIEDLAASLKFPLTKLFVVEGSKRSSHSNAYFYGLWN 264
            |:|:|:|..:|||||||:|||..|.||..||.:|.|:.||||||:|||||||||||||||||.:.
Zfish   204 LILVTIYADYIAPLFDKFTPLPDGELRSEIESMAKSISFPLTKLYVVEGSKRSSHSNAYFYGFFK 268

  Fly   265 SKRIVLFDTLL-----LNK--------GKPDDSELSE-----EEKGKGCTDEEVLAVLGHELGHW 311
            :||||||||||     ||:        |:.:::.::|     :.|.:||::.|||||||||||||
Zfish   269 NKRIVLFDTLLEDYSPLNQSGEKEPGTGEENEAVVNESKAKPKNKKQGCSNPEVLAVLGHELGHW 333

  Fly   312 KLGHVTKNIIIMQVHLFLMFLVFGNVFKYPPFYVAMGFQPGTRPILVGLLIVFTYVLAPYNALMN 376
            ||||..|||:|.|::.||.|.:|..:......::|.||. .|:|.|:||:|:|.::.:|||.|::
Zfish   334 KLGHTVKNIVISQMNSFLCFFLFAVLIGRKELFMAFGFH-DTQPTLIGLMIIFQFIFSPYNELLS 397

  Fly   377 FAMTILSRRFEYQADEFAFKLGFAEQLGQALIKLNVDNLGFPVYDWLYSTWNHSHPTLLQRLNRL 441
            |.||.||||||:|||.||..:|.:.:|..||||||.|||||||.|||:|.|::|||.||:||..|
Zfish   398 FCMTELSRRFEFQADAFARGMGRSSELYSALIKLNKDNLGFPVADWLFSMWHYSHPPLLERLRAL 462

  Fly   442 KELKEE 447
            ...|::
Zfish   463 TGPKQD 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24a	NP_611175.1	Peptidase_M48_N	31..216	CDD:293100	77/186 (41%)
		HtpX	153..440	CDD:223575	164/304 (54%)
		Peptidase_M48	219..439	CDD:279743	129/237 (54%)
zmpste24	NP_956186.1	Peptidase_M48_N	36..220	CDD:293100	77/186 (41%)
		HtpX	176..463	CDD:223575	154/287 (54%)
		Peptidase_M48	223..465	CDD:279743	131/242 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581872
Domainoid	1	1.000	257	1.000	Domainoid score	I1992
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4277
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1718
OMA	1	1.010	-	-		QHG61664
OrthoDB	1	1.010	-	-		D407946at33208
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	1	1.000	-	-		oto38881
orthoMCL	1	0.900	-	-		OOG6_101632
Panther	1	1.100	-	-	LDO	PTHR10120
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1406
SonicParanoid	1	1.000	-	-		X3698
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800