DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ste24a and SPAC3H1.05

DIOPT Version :9

Sequence 1:	NP_611175.1	Gene:	ste24a / 36908	FlyBaseID:	FBgn0034176	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_593547.1	Gene:	SPAC3H1.05 / 2543456	PomBaseID:	SPAC3H1.05	Length:	474	Species:	Schizosaccharomyces pombe

Alignment Length:	434	Identity:	172/434 - (39%)
Similarity:	243/434 - (55%)	Gaps:	43/434 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ALEIYISLRQVKVYQTALKVPAELKSHMGEDTFHKARKYGLDQEKFG-IFKAVVMDVALLCMELY 85
            |.::|:..|||. |....|.||.|..|:.|..:.||..|..|:..|. |.....:.|.||.:: |
pombe    61 AWDLYLRRRQVP-YLLREKPPAILAEHVDEKKYQKALSYARDKSWFSTIVSTFTLAVDLLIIK-Y 123

  Fly    86 IGLIAVLWQLSVQVVDKLQWDSK-----------NEIIVSCVFVLISNVLSTFKGLPFKIYKIFV 139
            .|| :.||.::     |..|..|           ..|..||||:....:.|....:||.:|..||
pombe   124 DGL-SYLWNIT-----KFPWMDKLAASSSRFSLSTSITHSCVFMFGLTLFSRLIQIPFNLYSTFV 182

  Fly   140 LEETHGFNKQTARFFAWDQLKGFLVTQVLMIPITAAIIFIVQRGGDNFFIWLWIFTGVISLVLLT 204
            :||.:||||.|.:.|..|.||...:..:||..:....:.|:.:.||||.::.|....|..|:|.|
pombe   183 IEEKYGFNKSTLKIFVIDLLKELSLGGLLMSVVVGVFVKILTKFGDNFIMYAWGAYIVFGLILQT 247

  Fly   205 LYPIFIAPLFDKYTPLEKGALRQSIEDLAASLKFPLTKLFVVEGSKRSSHSNAYFYGL-WNSKRI 268
            :.|..|.|||.|:||||.|:||..||:||||:.|||.||:|::.|:||:||||:|||| || |.|
pombe   248 IAPSLIMPLFYKFTPLENGSLRTQIEELAASINFPLKKLYVIDASRRSTHSNAFFYGLPWN-KGI 311

  Fly   269 VLFDTLLLNKGKPDDSELSEEEKGKGCTDEEVLAVLGHELGHWKLGHVTKNIII-MQVHLFLMFL 332
            ||||||:.|.                 |:.|::|:||||||||.:.|...|.|| ..:.||.:||
pombe   312 VLFDTLVKNH-----------------TEPELIAILGHELGHWYMSHNLINTIIDYGMSLFHLFL 359

  Fly   333 VFGNVFKYPPFYVAMGFQPGTRPILVGLLIVFTYVLAPYNALMNFAMTILSRRFEYQADEFAFKL 397
             |....:....|.:..|.. .:|::||||: |:..|.|.::::.||...:||..|||||.||.:|
pombe   360 -FAAFIRNNSLYTSFNFIT-EKPVIVGLLL-FSDALGPLSSILTFASNKVSRLCEYQADAFAKQL 421

  Fly   398 GFAEQLGQALIKLNVDNLGFPVYDWLYSTWNHSHPTLLQRLNRL 441
            |:|:.||..||:::.|||....:|.||:::.||||.|:.|||.:
pombe   422 GYAKDLGDGLIRIHDDNLSPLEFDSLYTSYYHSHPILVDRLNAI 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24a	NP_611175.1	Peptidase_M48_N	31..216	CDD:293100	65/196 (33%)
		HtpX	153..440	CDD:223575	124/288 (43%)
		Peptidase_M48	219..439	CDD:279743	100/221 (45%)
SPAC3H1.05	NP_593547.1	Peptidase_M48_N	73..259	CDD:293100	63/192 (33%)
		HtpX	205..474	CDD:223575	121/282 (43%)
		Peptidase_M48	262..468	CDD:279743	102/225 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	175	1.000	Domainoid score	I853
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4277
Inparanoid	1	1.050	269	1.000	Inparanoid score	I712
OMA	1	1.010	-	-		QHG61664
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	1	1.000	-	-		otm47042
orthoMCL	1	0.900	-	-		OOG6_101632
Panther	1	1.100	-	-	LDO	PTHR10120
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1406
SonicParanoid	1	1.000	-	-		X3698
TreeFam	1	0.960	-	-
	14	13.860