DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ste24a and fce-1

DIOPT Version :9

Sequence 1:	NP_611175.1	Gene:	ste24a / 36908	FlyBaseID:	FBgn0034176	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_492582.1	Gene:	fce-1 / 172820	WormBaseID:	WBGene00001405	Length:	442	Species:	Caenorhabditis elegans

Alignment Length:	434	Identity:	185/434 - (42%)
Similarity:	264/434 - (60%)	Gaps:	24/434 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YISLRQVKVYQTALKVPAELKSHMGEDTFHKARKYGLDQEKFGIFKAVVMDVALLCMELYIGLIA 90
            ||:.||.|.::.|:|.|.|:|..:||:.:.|||.|.:|...||.|.: ..:..||..:|..|...
Worm    23 YITFRQYKAHKNAVKRPNEVKELIGEEDYKKARDYKIDNHLFGFFHS-WFNQLLLTAQLIGGYYP 86

  Fly    91 VLWQLSVQVVDKLQWDSKNEIIVSCVFVLISNVLSTFKGLPFKIYKIFVLEETHGFNKQTARFFA 155
            .||           :.:.:..:...||:.|::::.|...||:.:|..|::|:.|||||||..|:.
Worm    87 FLW-----------YATASYPLHVAVFLSINSIIETIIDLPWDLYSTFIIEDAHGFNKQTIGFYF 140

  Fly   156 WDQLKGFLVTQVLMIPITAAIIFIVQRGGDNFFIWLWIFTGVISLVLLTLYPIFIAPLFDKYTPL 220
            .|::|..||...|.:||...|.:|:..||..||:::|:|..|:.|:|:|:||.|||||||||.||
Worm   141 VDKIKKMLVGFALTMPIVYGIEWIIVNGGPYFFVYIWLFVSVVVLLLMTIYPTFIAPLFDKYFPL 205

  Fly   221 EKGALRQSIEDLAASLKFPLTKLFVVEGSKRSSHSNAYFYGLWNSKRIVLFDTLLLNKGKPDDSE 285
            ..|.|:..||.|||||.:|||:|:||.|||||:|||||.||.|.:|||||:||||....|....|
Worm   206 PDGDLKTKIEQLAASLSYPLTELYVVNGSKRSAHSNAYMYGFWKNKRIVLYDTLLSGAEKEKVHE 270

  Fly   286 L----------SEEEKGKGCTDEEVLAVLGHELGHWKLGHVTKNIIIMQVHLFLMFLVFGNVFKY 340
            |          :|.:|.:|..::||:||||||||||.|.|...|::|.:|:||..|.|||..:|:
Worm   271 LYVAAGEKIEETENDKKRGMNNDEVVAVLGHELGHWALWHTLINLVITEVNLFFSFAVFGYFYKW 335

  Fly   341 PPFYVAMGFQPGTRPILVGLLIVFTYVLAPYNALMNFAMTILSRRFEYQADEFAFKLGFAEQLGQ 405
            ...|...|:.  ..|.::|::::|.:|||.||.|.:..|.|.||..|:.|||||..||..|.|..
Worm   336 EALYQGFGYH--DTPPVIGMMLIFQFVLALYNQLASIGMVIHSRSAEFGADEFAANLGHGENLIG 398

  Fly   406 ALIKLNVDNLGFPVYDWLYSTWNHSHPTLLQRLNRLKELKEEKK 449
            ||.||.||||..|:.|.|||...|:||.:::|:..::..:.:.|
Worm   399 ALTKLGVDNLSMPINDSLYSWCTHTHPPVVERVAAVRAFQAKNK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24a	NP_611175.1	Peptidase_M48_N	31..216	CDD:293100	67/184 (36%)
		HtpX	153..440	CDD:223575	142/296 (48%)
		Peptidase_M48	219..439	CDD:279743	111/229 (48%)
fce-1	NP_492582.1	Peptidase_M48_N	28..201	CDD:293100	67/184 (36%)
		HtpX	75..440	CDD:223575	164/377 (44%)
		Peptidase_M48	204..436	CDD:279743	111/233 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159919
Domainoid	1	1.000	212	1.000	Domainoid score	I1616
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4277
Inparanoid	1	1.050	348	1.000	Inparanoid score	I1359
Isobase	1	0.950	-	0	Normalized mean entropy	S1184
OMA	1	1.010	-	-		QHG61664
OrthoDB	1	1.010	-	-		D407946at33208
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	1	1.000	-	-		oto17868
orthoMCL	1	0.900	-	-		OOG6_101632
Panther	1	1.100	-	-	LDO	PTHR10120
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1406
SonicParanoid	1	1.000	-	-		X3698
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790