Protein Alignment ste24a and OMA1

DIOPT Version :9

• Sequence 1: NP_611175.1
• Gene: ste24a / 36908
• FlyBaseID: FBgn0034176
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_660286.1
• Gene: OMA1 / 115209
• HGNCID: 29661
• Length: 524
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 92/461 - (19%)
• Similarity: 161/461 - (34%)
• Gaps: 158/461 - (34%)

  Fly   115 CVFVLISNVLSTFKGL-------------PFKIYKIFVLEETHGFN--------KQTARFFAWDQ 158
            |..|.::::::.::||             .|..|..|..:.|.|.:        :.|::...|:.
Human    38 CHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWND 102

  Fly   159 L--KGFLVTQVLMI-------PITAAIIFIVQRGGDNFFIWLWIFTGVISLVLLTLYPI------ 208
            .  :..|:.:|..:       |::.|.|..::    ||..........:.|:|:.|.|:
Human   103 AFSRQLLIKEVTAVPSLSVLHPLSPASIRAIR----NFHTSPRFQAAPVPLLLMILKPVQKLFAI 163

  Fly   209 ----FIAPLFDKYTPLEKGALRQSIEDLAASLKFPLTK---LFVV------EGSKRSSHSNAYF- 259
                .|...:....|.:|..::::|......|...|:.   ||||      |.|..:..|....
Human   164 IVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLL 228

  Fly   260 ------------YGLWNSK----------------RIVLFDTLLLNKGKPDDSELS--------- 287
                        |..|..:                :.||...:..||..|..|:::
Human   229 GKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSP 293

  Fly   288 -----EEEKGK---------GCTDEEVLA-VLGHELGHWKLGHVTKNIIIMQVHLFLMFLVFGNV 337
                 ....|:         ..||...|: :||||:.|..|||..:.  ...||| |.||  |.:
Human   294 IINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEK--AGMVHL-LDFL--GMI 353

  Fly   338 FKYPPFYVAMGFQPGTRPILVGLLIVFTYVLAPYNALMNFAMTILSRRFEYQADE-FAFKL-GFA 400
            |                       :...:.:.|.::|......|.|:..||..:. ::.|| ..|
Human   354 F-----------------------LTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEA 395

  Fly   401 EQLGQAL-------IKLN---------VDNL-GFP-VYDWLYSTWNHSHPTLLQRLNRL--KELK 445
            :::|..|       |:.:         ||:| |.| :.:|| || :.||...::.|:||  :.||
Human   396 DKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWL-ST-HPSHGNRVEYLDRLIPQALK 458

  Fly   446 EEKKLN 451
            ..:..|
Human   459 IREMCN 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ste24a	NP_611175.1	Peptidase_M48_N	31..216	CDD:293100	23/140 (16%)
		HtpX	153..440	CDD:223575	77/387 (20%)
		Peptidase_M48	219..439	CDD:279743	63/301 (21%)
OMA1	NP_660286.1	Cardiolipin-binding. /evidence=ECO:0000250|UniProtKB:Q9D8H7	148..167		4/18 (22%)
		Stress-sensor region. /evidence=ECO:0000250|UniProtKB:Q9D8H7	165..195		4/29 (14%)
		M48C_Oma1_like	263..456	CDD:320690	52/222 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900