DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ste24a and ZMPSTE24

DIOPT Version :9

Sequence 1:	NP_611175.1	Gene:	ste24a / 36908	FlyBaseID:	FBgn0034176	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_005848.2	Gene:	ZMPSTE24 / 10269	HGNCID:	12877	Length:	475	Species:	Homo sapiens

Alignment Length:	443	Identity:	219/443 - (49%)
Similarity:	302/443 - (68%)	Gaps:	22/443 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EIYISLRQVKVYQTALKVPAELKSHMGEDTFHKARKYGLDQEKFGIFKAVVMDVALLCMELYIGL 88
            |.:::.||.::|:|...||.||...|..:||.|:|.|.||:..|..:..:..:.....:.|: |.
Human    34 ETFLAQRQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEGTLILLF-GG 97

  Fly    89 IAVLWQLSVQVVDKLQWDSKNEIIVSCVFVLISNVLSTFKGLPFKIYKIFVLEETHGFNKQTARF 153
            |..||:||.:......:..:.||..|.||:|::.:.|...|||:.:|..||:||.||||:||..|
Human    98 IPYLWRLSGRFCGYAGFGPEYEITQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQTLGF 162

  Fly   154 FAWDQLKGFLVTQVLMIPITAAIIFIVQRGGDNFFIWLWIFTGVISLVLLTLYPIFIAPLFDKYT 218
            |..|.:|.|:|||.:::|:::.:::|::.|||.|||:.|:||.|:||||:|:|..:|||||||:|
Human   163 FMKDAIKKFVVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFT 227

  Fly   219 PLEKGALRQSIEDLAASLKFPLTKLFVVEGSKRSSHSNAYFYGLWNSKRIVLFDTLL-----LNK 278
            ||.:|.|::.||.:|.|:.|||||::|||||||||||||||||.:.:||||||||||     |||
Human   228 PLPEGKLKEEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVLNK 292

  Fly   279 GKPDDSEL---------SEEEKGK------GCTDEEVLAVLGHELGHWKLGHVTKNIIIMQVHLF 328
            ...:||.:         |||.|.|      ||.:||||||||||||||||||..|||||.|::.|
Human   293 DIQEDSGMEPRNEEEGNSEEIKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSF 357

  Fly   329 LMFLVFGNVFKYPPFYVAMGFQPGTRPILVGLLIVFTYVLAPYNALMNFAMTILSRRFEYQADEF 393
            |.|.:|..:......:.|.||. .::|.|:||||:|.::.:|||.:::|.:|:||||||:|||.|
Human   358 LCFFLFAVLIGRKELFAAFGFY-DSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAF 421

  Fly   394 AFKLGFAEQLGQALIKLNVDNLGFPVYDWLYSTWNHSHPTLLQRLNRLKELKE 446
            |.|||.|:.|..||||||.|||||||.|||:|.|::|||.||:||..||.:|:
Human   422 AKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLLERLQALKTMKQ 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24a	NP_611175.1	Peptidase_M48_N	31..216	CDD:293100	75/184 (41%)
		HtpX	153..440	CDD:223575	170/306 (56%)
		Peptidase_M48	219..439	CDD:279743	135/239 (56%)
ZMPSTE24	NP_005848.2	Peptidase_M48_N	41..225	CDD:293100	75/184 (41%)
		HtpX	124..475	CDD:223575	191/352 (54%)
		Peptidase_M48	228..472	CDD:279743	138/244 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147976
Domainoid	1	1.000	262	1.000	Domainoid score	I1964
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4277
Inparanoid	1	1.050	422	1.000	Inparanoid score	I1786
Isobase	1	0.950	-	0	Normalized mean entropy	S1184
OMA	1	1.010	-	-		QHG61664
OrthoDB	1	1.010	-	-		D407946at33208
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	1	1.000	-	-		oto88723
orthoMCL	1	0.900	-	-		OOG6_101632
Panther	1	1.100	-	-	LDO	PTHR10120
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1406
SonicParanoid	1	1.000	-	-		X3698
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750