DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ste24b and Oma1

DIOPT Version :9

Sequence 1:	NP_611174.1	Gene:	ste24b / 36907	FlyBaseID:	FBgn0034175	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_080185.1	Gene:	Oma1 / 67013	MGIID:	1914263	Length:	521	Species:	Mus musculus

Alignment Length:	307	Identity:	69/307 - (22%)
Similarity:	102/307 - (33%)	Gaps:	110/307 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LYLQSLILTMIVLLLIPFMIHPFVGQS----VPLENSNLRTQLE-------------------YL 233
            |.|.:..|..:|.......:.|..|:|    |..|:..|.:.||                   ||
Mouse   193 LGLSAFGLLFVVFYFTHLEVSPVTGRSKLLLVGKEHFRLLSDLEYEVWMEEFKNDLLPERDPRYL 257

  Fly   234 T-RQVGFPMSQVR-----------IIRVHDPNTGSNAFFY--GCCCLKRIVIFDTLLLNRGKSDL 284
            | :::.:.::|..           ::.|.| :...|||..  |     ::.|| |.||| ..:|:
Mouse   258 TVKEMVYHLTQCNRDVPGISETNWVVHVVD-SPAVNAFVLPNG-----QVFIF-TGLLN-SVTDV 314

  Fly   285 SHLTAEELGRGLADPQVVAVVAHELGHWRNGHFYKAIMAFQVHLILTILLFAFLFSHGPIYQAVG 349
            ..|:              .::.||:.|...||  .|..|..||| |..|...||
Mouse   315 HQLS--------------FLLGHEIAHAVLGH--AAEKASLVHL-LDFLGMIFL----------- 351

  Fly   350 FPPGLQPTVIGCLIIFGFVLTPYMTLANFSMLSMTRCFEYQADRFAYQLGYGGELRQALLKLYA- 413
                   |:|       :.:.|..:||.......::..||..|| .|......|..:..|:|.|
Mouse   352 -------TMI-------WAICPRDSLAVLGQWIQSKLQEYMFDR-PYSRTLEAEADKVGLQLAAK 401

  Fly   414 ------------DNLAFPVS---DPCYSSWNHTHPT------MLDRL 439
                        ..:.|..|   .|....|..|||:      .||||
Mouse   402 ACADVRASSVFWQQMEFSESLHGYPKLPEWLSTHPSHGNRAEYLDRL 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24b	NP_611174.1	Peptidase_M48_N	35..214	CDD:293100	4/21 (19%)
		HtpX	167..444	CDD:223575	69/307 (22%)
		Peptidase_M48	220..444	CDD:279743	61/275 (22%)
Oma1	NP_080185.1	Cardiolipin-binding. /evidence=ECO:0000269\|PubMed:31819158	144..163
		Stress-sensor region. /evidence=ECO:0000269\|PubMed:24550258	161..191
		M48C_Oma1_like	265..452	CDD:320690	54/235 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900