DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ste24b and Zmpste24

DIOPT Version :9

Sequence 1:	NP_611174.1	Gene:	ste24b / 36907	FlyBaseID:	FBgn0034175	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_001101444.1	Gene:	Zmpste24 / 313564	RGDID:	1305570	Length:	475	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	144/479 - (30%)
Similarity:	249/479 - (51%)	Gaps:	52/479 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WDDPL--AILYIIIAFLVLDNLWGVYLMLRDIQVAYKTQQVPNVISPYLPQELYDKMRVYKIHKG 68
            ||.|.  .|...::.|.....||..:|..|..::...|..||..:...:..:.::|.|:|::.|.
  Rat    11 WDFPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTHVPPELEQIMDSDTFEKSRLYQLDKS 75

  Fly    69 WFTIVNTLLSAVILGIMELYFGFYAWLYGVAGKCALSKWM--EHEACVSVIFVLLLSVYFWLKSV 131
            .|:..:.|.|.| .|...|.||...:|:.::|:...|...  |:|...|::|:||.:::..|..:
  Rat    76 TFSFWSGLYSEV-EGTFILLFGGIPYLWRLSGRFCSSAGFGPEYEIIQSLVFLLLATLFSALTGL 139

  Fly   132 PAMIYESCCI--------KSLQPRPKPPWWSRICHFVVDLVVGAMITTLVVV----ALVYMF-IG 183
            |..:|.:..|        ::|:            .|:.|.:...::|..:::    .|:|:. ||
  Rat   140 PWSLYNTFVIEEKHGFNHQTLE------------FFMKDAIKKFIVTQCILLPVSSLLLYIIKIG 192

  Fly   184 LGPYAPLGLYLQSLILTMIVLLLIPFMIHPFVGQSVPLENSNLRTQLEYLTRQVGFPMSQVRIIR 248
             |.|..:..:|.:|:::::::.:....|.|...:..||....|:.::|.:.:.:.||:::|.::.
  Rat   193 -GDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEVMAKSIDFPLTKVYVVE 256

  Fly   249 VHDPNTGSNAFFYGCCCLKRIVIFDTLL------------------LNRGKSDLSHLTAEELGR- 294
            ....::.|||:|||....||||:|||||                  .|.|:.|...:.::...:
  Rat   257 GSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVPNKDNQEEPGLEPRNEGEGDSEEVKSKVKNKK 321

  Fly   295 -GLADPQVVAVVAHELGHWRNGHFYKAIMAFQVHLILTILLFAFLFSHGPIYQAVGFPPGLQPTV 358
             |..:.:|:||:.||||||:.||..|.|:..|::..|...|||.|.....::.|.||... |||:
  Rat   322 QGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRRELFAAFGFYDS-QPTL 385

  Fly   359 IGCLIIFGFVLTPYMTLANFSMLSMTRCFEYQADRFAYQLGYGGELRQALLKLYADNLAFPVSDP 423
            ||.||||.|:.:||..:.:|.:..::|.||:|||.||.:||...:|..||:||..|||.|||||.
  Rat   386 IGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDW 450

  Fly   424 CYSSWNHTHPTMLDRLSRLEEFRR 447
            .:|:|:::||.:|:||..|:..:|
  Rat   451 LFSTWHYSHPPLLERLQALKNAKR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ste24b	NP_611174.1	Peptidase_M48_N	35..214	CDD:293100	41/193 (21%)
		HtpX	167..444	CDD:223575	103/301 (34%)
		Peptidase_M48	220..444	CDD:279743	92/243 (38%)
Zmpste24	NP_001101444.1	Peptidase_M48_N	41..225	CDD:293100	42/197 (21%)
		HtpX	124..474	CDD:223575	113/363 (31%)
		Peptidase_M48	228..471	CDD:279743	92/243 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341846
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61664
OrthoDB	1	1.010	-	-		D407946at33208
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10120
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.820