Protein Alignment ste24b and ZMPSTE24

DIOPT Version :10

• Sequence 1: NP_611174.1
• Gene: ste24b / 36907
• FlyBaseID: FBgn0034175
• Length: 447
• Species: Drosophila melanogaster
• Sequence 2: NP_005848.2
• Gene: ZMPSTE24 / 10269
• HGNCID: 12877
• Length: 475
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 142/471 - (30%)
• Similarity: 249/471 - (52%)
• Gaps: 36/471 - (7%)

  Fly     6 WDDPL--AILYIIIAFLVLDNLWGVYLMLRDIQVAYKTQQVPNVISPYLPQELYDKMRVYKIHKG 68
            |:.|.  .|...::.|.....||..:|..|..::...|..||..:...:..|.::|.|:|::.|.
Human    11 WEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKS 75

  Fly    69 WFTIVNTLLSAVILGIMELYFGFYAWLYGVAGK-CALSKW-MEHEACVSVIFVLLLSVYFWLKSV 131
            .|:..:.|.|.. .|.:.|.||...:|:.::|: |..:.: .|:|...|::|:||.:::..|..:
Human    76 TFSFWSGLYSET-EGTLILLFGGIPYLWRLSGRFCGYAGFGPEYEITQSLVFLLLATLFSALTGL 139

  Fly   132 PAMIYESCCIKSLQPRPKPPWWSRICHFVVDLVVGAMITTLVVV----ALVYMF-IGLGPYAPLG 191
            |..:|.:..|:......:    ..:..|:.|.:...::|..:::    .|:|:. || |.|..:.
Human   140 PWSLYNTFVIEEKHGFNQ----QTLGFFMKDAIKKFVVTQCILLPVSSLLLYIIKIG-GDYFFIY 199

  Fly   192 LYLQSLILTMIVLLLIPFMIHPFVGQSVPLENSNLRTQLEYLTRQVGFPMSQVRIIRVHDPNTGS 256
            .:|.:|:::::::.:....|.|...:..||....|:.::|.:.:.:.||:::|.::.....::.|
Human   200 AWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEGSKRSSHS 264

  Fly   257 NAFFYGCCCLKRIVIFDTLL-----LNR---------------GKSDLSHLTAEELGRGLADPQV 301
            ||:|||....||||:|||||     ||:               |.|:......:...:|..:.:|
Human   265 NAYFYGFFKNKRIVLFDTLLEEYSVLNKDIQEDSGMEPRNEEEGNSEEIKAKVKNKKQGCKNEEV 329

  Fly   302 VAVVAHELGHWRNGHFYKAIMAFQVHLILTILLFAFLFSHGPIYQAVGFPPGLQPTVIGCLIIFG 366
            :||:.||||||:.||..|.|:..|::..|...|||.|.....::.|.||... |||:||.||||.
Human   330 LAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELFAAFGFYDS-QPTLIGLLIIFQ 393

  Fly   367 FVLTPYMTLANFSMLSMTRCFEYQADRFAYQLGYGGELRQALLKLYADNLAFPVSDPCYSSWNHT 431
            |:.:||..:.:|.:..::|.||:|||.||.:||...:|..||:||..|||.|||||..:|.|:::
Human   394 FIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYS 458

  Fly   432 HPTMLDRLSRLEEFRR 447
            ||.:|:||..|:..::
Human   459 HPPLLERLQALKTMKQ 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ste24b	NP_611174.1	M48A_Zmpste24p_like	14..444	CDD:320702	139/456 (30%)
ZMPSTE24	NP_005848.2	M48A_Zmpste24p_like	22..470	CDD:320702	138/454 (30%)