DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbp53E and CALM1

DIOPT Version :9

Sequence 1:	NP_001286511.1	Gene:	Cbp53E / 36905	FlyBaseID:	FBgn0004580	Length:	310	Species:	Drosophila melanogaster
Sequence 2:	NP_001350599.1	Gene:	CALM1 / 801	HGNCID:	1442	Length:	150	Species:	Homo sapiens

Alignment Length:	183	Identity:	47/183 - (25%)
Similarity:	83/183 - (45%)	Gaps:	35/183 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ESRELKKLSANQFMDVWAHYDKDGNGYIEGTELDGFLREFVSSANATDISPEAVTDTMLEELKSC 92
            ::.:|.:....:|.:.::.:||||:|.|...||...:|..  ..|.|    ||....|:.|:
Human     2 QADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSL--GQNPT----EAELQDMINEV--- 57

  Fly    93 FMEAYDDNQDGKIDIRELAQLLPMEENFL-LLFRFDNPLESSVEFMKIWREYDTDNSGYIEADEL 156
                 |.:.:|.||..|          || ::.|.....:|..|..:.:|.:|.|.:|||.|.||
Human    58 -----DADGNGTIDFPE----------FLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAEL 107

  Fly   157 KNFLRDLLKEAKKINDVSEDKLIEYTDTMLQVFDANKDGRLQLSEMAKLLPVK 209
            ::.:.:|   .:|:.|       |..|.|::..|.:.||::...|..:::..|
Human   108 RHVMTNL---GEKLTD-------EEVDEMIREADIDGDGQVNYEEFVQMMTAK 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbp53E	NP_001286511.1	EFh_HEF_CBN	40..301	CDD:320079	46/171 (27%)
		EF-hand motif	40..68	CDD:320079	10/27 (37%)
		EF-hand motif	89..118	CDD:320079	5/28 (18%)
		EF-hand motif	135..164	CDD:320079	10/28 (36%)
		EF-hand motif	181..210	CDD:320079	7/29 (24%)
		EF-hand motif	228..257	CDD:320079
		EF-hand motif	273..301	CDD:320079
CALM1	NP_001350599.1	PTZ00184	3..150	CDD:185504	46/180 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910