DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbp53E and calb2b

DIOPT Version :9

Sequence 1:	NP_001286511.1	Gene:	Cbp53E / 36905	FlyBaseID:	FBgn0004580	Length:	310	Species:	Drosophila melanogaster
Sequence 2:	NP_957005.1	Gene:	calb2b / 393684	ZFINID:	ZDB-GENE-040426-1668	Length:	269	Species:	Danio rerio

Alignment Length:	274	Identity:	129/274 - (47%)
Similarity:	177/274 - (64%)	Gaps:	18/274 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DPESRELKKLSANQFMDVWAHYDKDGNGYIEGTELDGFLREFVSSANATDISPEAVTDTMLEELK 90
            :|.|..|.:|:|:||:|:|..:|.||||.|||.||:.|:||...:....|.|..:..|.|.|
Zfish     7 EPISLHLAELTASQFLDIWNKFDADGNGCIEGKELENFIRELEIARKTADPSNASFKDRMKE--- 68

  Fly    91 SCFMEAYDDNQDGKIDIRELAQLLPMEENFLLLFRFDNPLESSVEFMKIWREYDTDNSGYIEADE 155
              ||:.:|:|.||||::.||||:||.||||||.||  ..:.||.|||..||:||||.|||||::|
Zfish    69 --FMQKFDENGDGKIEMSELAQILPTEENFLLCFR--QFVGSSAEFMTAWRKYDTDRSGYIESNE 129

  Fly   156 LKNFLRDLLKEAKKINDVSEDKLIEYTDTMLQVFDANKDGRLQLSEMAKLLPVKENFLCR-QVFK 219
            ||.||.||||:|.:  ..::.||.|||.|:|::||.|.||:|.|||||:||||:||||.: |.|
Zfish   130 LKGFLSDLLKKANR--HYNDKKLNEYTQTILKMFDLNGDGKLGLSEMARLLPVEENFLLKFQNF- 191

  Fly   220 GATKLTKEDIEKVFSLYDRDNSGTIENEELKGFLKDLLELVKKDDYDAQDLAAFEETIMRGVGTD 284
               ||:.|:.|.:|:.||:|.:|.|:..||...|:||.. ..|...|...|::.:::||   ...
Zfish   192 ---KLSAEEFEAIFNYYDKDGNGYIDEHELDALLRDLYH-KHKMAVDPHSLSSSKKSIM---ALS 249

  Fly   285 KHGKISRKELTMIL 298
            ..||:.|.||.::|
Zfish   250 DGGKLFRTELEIVL 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbp53E	NP_001286511.1	EFh_HEF_CBN	40..301	CDD:320079	123/260 (47%)
		EF-hand motif	40..68	CDD:320079	16/27 (59%)
		EF-hand motif	89..118	CDD:320079	14/28 (50%)
		EF-hand motif	135..164	CDD:320079	20/28 (71%)
		EF-hand motif	181..210	CDD:320079	19/28 (68%)
		EF-hand motif	228..257	CDD:320079	11/28 (39%)
		EF-hand motif	273..301	CDD:320079	8/26 (31%)
calb2b	NP_957005.1	PTZ00184	13..178	CDD:185504	91/173 (53%)
		EFh	20..90	CDD:238008	34/74 (46%)
		EFh	109..178	CDD:238008	42/70 (60%)
		EF-hand_7	155..218	CDD:290234	33/66 (50%)
		EFh	157..223	CDD:238008	34/69 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574424
Domainoid	1	1.000	90	1.000	Domainoid score	I7756
eggNOG	1	0.900	-	-		E33208_3BHMG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48379
OrthoDB	1	1.010	-	-		D415503at33208
OrthoFinder	1	1.000	-	-		FOG0003230
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104970
Panther	1	1.100	-	-	O	PTHR19972
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.720