DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbp53E and Scgn

DIOPT Version :9

Sequence 1:	NP_001286511.1	Gene:	Cbp53E / 36905	FlyBaseID:	FBgn0004580	Length:	310	Species:	Drosophila melanogaster
Sequence 2:	NP_663374.1	Gene:	Scgn / 214189	MGIID:	2384873	Length:	276	Species:	Mus musculus

Alignment Length:	281	Identity:	118/281 - (41%)
Similarity:	177/281 - (62%)	Gaps:	23/281 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KLSANQFMDVWAHYDKDGNGYIEGTELDGFLREFVSSANATDISPEAVTDTMLEE----LKSCFM 94
            :|.|..|..:|..:||:..|||..||||.|....::.:        ...||::||    :|...|
Mouse    11 RLDAACFWQIWQRFDKEEKGYIRETELDAFFDHLLAKS--------GTEDTLMEENVQKVKEQLM 67

  Fly    95 EAYDDNQDGKIDIRELAQL-LPMEENFLLLFRFDNPLESSVEFMKIWREYDTDNSGYIEADELKN 158
            .:::.:::|:|.::|||.: |..:|||||.||.:.||::|||||:|||:||.|:||:|.|.||.|
Mouse    68 TSHNVSKEGRILMKELASMFLSEDENFLLFFRLETPLDNSVEFMQIWRKYDADSSGFISAAELCN 132

  Fly   159 FLRDLLKEAKKINDVSEDKLIEYTDTMLQVFDANKDGRLQLSEMAKLLPVKENFLCRQVFK---G 220
            |||||....||  ::||.:|.|||.||:::||.||||||.|:::|::|.::||||.:  ||   .
Mouse   133 FLRDLFLHHKK--NISEAELEEYTSTMMKIFDKNKDGRLDLNDLARILALQENFLLQ--FKMDAS 193

  Fly   221 ATKLTKEDIEKVFSLYDRDNSGTIENEELKGFLKDLLELVKKDDYDAQDLAAFEETIMRGVGTDK 285
            :|:..|.|.||:|:.||...:|.:|..|:.||:||::||| :......||..|.|.::|....:|
Mouse   194 STEERKRDFEKIFAHYDVSKTGALEGPEVDGFVKDMMELV-QPSISGVDLDKFREILLRHCDVNK 257

  Fly   286 HGKISRKELTMILLTLAKISP 306
            .|||.:.||.:.|  ..||:|
Mouse   258 DGKIQKSELALCL--GLKINP 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbp53E	NP_001286511.1	EFh_HEF_CBN	40..301	CDD:320079	113/268 (42%)
		EF-hand motif	40..68	CDD:320079	12/27 (44%)
		EF-hand motif	89..118	CDD:320079	8/29 (28%)
		EF-hand motif	135..164	CDD:320079	20/28 (71%)
		EF-hand motif	181..210	CDD:320079	15/28 (54%)
		EF-hand motif	228..257	CDD:320079	13/28 (46%)
		EF-hand motif	273..301	CDD:320079	10/27 (37%)
Scgn	NP_663374.1	EFh	109..179	CDD:238008	41/71 (58%)
Scgn	NP_663374.1	EF-hand_7	111..178	CDD:290234	39/68 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831420
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5088
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48379
OrthoDB	1	1.010	-	-		D415503at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104970
Panther	1	1.100	-	-	O	PTHR19972
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.820