DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbp53E and tnc-2

DIOPT Version :9

Sequence 1:	NP_001286511.1	Gene:	Cbp53E / 36905	FlyBaseID:	FBgn0004580	Length:	310	Species:	Drosophila melanogaster
Sequence 2:	NP_496251.1	Gene:	tnc-2 / 174612	WormBaseID:	WBGene00006583	Length:	160	Species:	Caenorhabditis elegans

Alignment Length:	178	Identity:	51/178 - (28%)
Similarity:	87/178 - (48%)	Gaps:	32/178 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LKKLSAN---QFMDVWAHYDKDGNGYIEGTELDGFLREFVSSANATDISPEAVTDTMLEELKSCF 93
            |:||||:   ||...:..:||:|.|||..|::...||..          .:|..:..|::|
Worm     9 LEKLSADQIEQFRKYFNMFDKEGKGYIRATQVGQILRTM----------GQAFEERDLKQL---- 59

  Fly    94 MEAYDDNQDGKIDIRELAQLLPMEENFLLLFRFDNPLESSVEFMKIWREYDTDNSGYIEADELKN 158
            ::.:|.:..|:|:..|.|   .|..||::....|..||.  |..:.:|.||.:.:|||...:|::
Worm    60 IKEFDADGSGEIEFEEFA---AMVANFVVNNENDEGLEE--ELREAFRLYDKEGNGYINVSDLRD 119

  Fly   159 FLRDLLKEAKKINDVSEDKLIEYTDTMLQVFDANKDGRLQLSEMAKLL 206
            .||.|      .::|||::|    |.|:...||:..|.:...|..:::
Worm   120 ILRAL------DDNVSEEEL----DEMIAEIDADGSGTVDFDEFMEMM 157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbp53E	NP_001286511.1	EFh_HEF_CBN	40..301	CDD:320079	45/167 (27%)
		EF-hand motif	40..68	CDD:320079	10/27 (37%)
		EF-hand motif	89..118	CDD:320079	7/28 (25%)
		EF-hand motif	135..164	CDD:320079	10/28 (36%)
		EF-hand motif	181..210	CDD:320079	6/26 (23%)
		EF-hand motif	228..257	CDD:320079
		EF-hand motif	273..301	CDD:320079
tnc-2	NP_496251.1	PTZ00184	10..157	CDD:185504	50/175 (29%)
		EFh	19..81	CDD:238008	20/78 (26%)
		EFh	96..158	CDD:238008	21/72 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5029
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860