DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbp53E and calb2

DIOPT Version :9

Sequence 1:	NP_001286511.1	Gene:	Cbp53E / 36905	FlyBaseID:	FBgn0004580	Length:	310	Species:	Drosophila melanogaster
Sequence 2:	XP_031756696.1	Gene:	calb2 / 100496513	XenbaseID:	XB-GENE-960001	Length:	272	Species:	Xenopus tropicalis

Alignment Length:	274	Identity:	136/274 - (49%)
Similarity:	181/274 - (66%)	Gaps:	14/274 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RDPESRELKKLSANQFMDVWAHYDKDGNGYIEGTELDGFLREFVSSANATDISPEAVTDTMLEEL 89
            :.|....|.:|:|:||:|:|.|||.||||||||.||:.|.||..::.....:  :|......|:|
Frog     5 QQPLYLHLAELTASQFLDIWKHYDSDGNGYIEGKELENFFRELEAARRGAGV--DASNVNFGEKL 67

  Fly    90 KSCFMEAYDDNQDGKIDIRELAQLLPMEENFLLLFRFDNPLESSVEFMKIWREYDTDNSGYIEAD 154
            |. ||:.||.|.||:|::.||||:||.||||||.||  ....||:|||:.||:||||.||||||:
Frog    68 KE-FMQKYDKNADGRIEMAELAQILPTEENFLLCFR--QHAGSSIEFMEAWRKYDTDRSGYIEAN 129

  Fly   155 ELKNFLRDLLKEAKKINDVSEDKLIEYTDTMLQVFDANKDGRLQLSEMAKLLPVKENFLCRQVFK 219
            |||.||.||||:|.:..|  |.||.|||.|:|::||.|.||:|.||||::||||:||||.:  |:
Frog   130 ELKGFLSDLLKKANRPFD--EKKLHEYTQTILRMFDLNGDGKLCLSEMSRLLPVQENFLLK--FQ 190

  Fly   220 GATKLTKEDIEKVFSLYDRDNSGTIENEELKGFLKDLLELVKKDDYDAQDLAAFEETIMRGVGTD 284
            | .||:.::...:||.||:|.||.|:..||...|||..|..|| |.|.|.|..:.::||   ...
Frog   191 G-MKLSSDEFNSIFSFYDKDGSGYIDENELDALLKDFFEKNKK-DVDIQSLTGYRQSIM---SLC 250

  Fly   285 KHGKISRKELTMIL 298
            ..|::.||||.::|
Frog   251 DGGRLYRKELEIVL 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbp53E	NP_001286511.1	EFh_HEF_CBN	40..301	CDD:320079	131/259 (51%)
		EF-hand motif	40..68	CDD:320079	19/27 (70%)
		EF-hand motif	89..118	CDD:320079	16/28 (57%)
		EF-hand motif	135..164	CDD:320079	21/28 (75%)
		EF-hand motif	181..210	CDD:320079	18/28 (64%)
		EF-hand motif	228..257	CDD:320079	13/28 (46%)
		EF-hand motif	273..301	CDD:320079	8/26 (31%)
calb2	XP_031756696.1	EFh_HEF_CR	20..267	CDD:320077	131/259 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9106
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3250
OMA	1	1.010	-	-		QHG48379
OrthoDB	1	1.010	-	-		D415503at33208
OrthoFinder	1	1.000	-	-		FOG0003230
OrthoInspector	1	1.000	-	-		otm49057
Panther	1	1.100	-	-	O	PTHR19972
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.080