DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbp53E and calb1

DIOPT Version :9

Sequence 1:	NP_001286511.1	Gene:	Cbp53E / 36905	FlyBaseID:	FBgn0004580	Length:	310	Species:	Drosophila melanogaster
Sequence 2:	XP_001341604.1	Gene:	calb1 / 100001650	ZFINID:	ZDB-GENE-030131-8107	Length:	260	Species:	Danio rerio

Alignment Length:	265	Identity:	128/265 - (48%)
Similarity:	172/265 - (64%)	Gaps:	19/265 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KLSANQFMDVWAHYDKDGNGYIEGTELDGFLREFVSSANATDISPEAVTDTMLEELKSCFMEAYD 98
            ::||:||:|::.|||.||||:|||.||..|::|...:.....:.   :||.|     ..|:|.|:
Zfish    10 EISASQFLDIFHHYDNDGNGFIEGKELQNFIKELQQARKQAGLE---LTDKM-----KAFVEKYE 66

  Fly    99 DNQDGKIDIRELAQLLPMEENFLLLFRFDNPLESSVEFMKIWREYDTDNSGYIEADELKNFLRDL 163
            .|.||||.|.||.|:||.||||||.||  ..|:|..|||:.||.||.|:|||||||||||||:||
Zfish    67 QNADGKIGIIELVQILPTEENFLLFFR--QQLKSCAEFMEAWRIYDADHSGYIEADELKNFLKDL 129

  Fly   164 LKEAKKINDVSEDKLIEYTDTMLQVFDANKDGRLQLSEMAKLLPVKENFLCRQVFKGATKLTKED 228
            |:.|||..|  |.||.|||.|.|::||:||||:|.|||||:|||..||||.:  |:| .|:.:::
Zfish   130 LQRAKKPYD--EKKLEEYTLTTLKIFDSNKDGKLCLSEMARLLPDNENFLLK--FQG-VKMARKE 189

  Fly   229 IEKVFSLYDRDNSGTIENEELKGFLKDLLELVKKDDYDAQDLAAFEETIMRGVGTDKHGKISRKE 293
            ..|:|.|||:|.:|.::..||...||||.|...| ..:|..::.::..||   .....||:.|.|
Zfish   190 FNKIFELYDKDRNGYMDENELDALLKDLCEKNNK-VLEANKISTYKSAIM---ALSDGGKLYRTE 250

  Fly   294 LTMIL 298
            |.::|
Zfish   251 LALVL 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbp53E	NP_001286511.1	EFh_HEF_CBN	40..301	CDD:320079	125/259 (48%)
		EF-hand motif	40..68	CDD:320079	16/27 (59%)
		EF-hand motif	89..118	CDD:320079	14/28 (50%)
		EF-hand motif	135..164	CDD:320079	22/28 (79%)
		EF-hand motif	181..210	CDD:320079	19/28 (68%)
		EF-hand motif	228..257	CDD:320079	12/28 (43%)
		EF-hand motif	273..301	CDD:320079	8/26 (31%)
calb1	XP_001341604.1	PTZ00184	14..170	CDD:185504	92/167 (55%)
		EFh	15..82	CDD:238008	32/74 (43%)
		EFh	101..170	CDD:238008	48/70 (69%)
		EFh	151..215	CDD:238008	31/66 (47%)
		EF-hand_7	151..210	CDD:290234	29/61 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574422
Domainoid	1	1.000	90	1.000	Domainoid score	I7756
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48379
OrthoDB	1	1.010	-	-		D415503at33208
OrthoFinder	1	1.000	-	-		FOG0003230
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8251
SonicParanoid	1	1.000	-	-		X2186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.990