DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ITGB3 and Itgbn

DIOPT Version :9

Sequence 1:	NP_000203.2	Gene:	ITGB3 / 3690	HGNCID:	6156	Length:	788	Species:	Homo sapiens
Sequence 2:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	790	Identity:	254/790 - (32%)
Similarity:	389/790 - (49%)	Gaps:	84/790 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    34 RGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESI--EFPVSEARVLEDRPLS 96
            |...||::||:....||||:|:...:|. ||..:..||..||:...|  ..||.:  ||:|:||.
  Fly    34 RHADSCERCLSAHLECAWCTDKEYQVGY-RCLSRRQLLNYNCSETDIYENQPVLD--VLQDKPLK 95

Human    97 DKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLG 161
            |..:.|  |..||:|||..|:|...:::...:..|...:.|:|:|.||||:::|:||..:::.||
  Fly    96 DYETSD--QAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELG 158

Human   162 TKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQV 226
            .:|:..::.||.|.|:|||:|.|||..|.:.   |:..||||...:.||.|.:||:|.|:|||.:
  Fly   159 AQLSQTLKNLTGNYRLGFGSFADKPTLPMIL---PQHRENPCAAERATCEPTYGYRHQLSLTDDI 220

Human   227 TRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGI 291
            ..|...|....::.|.|..|||.||:||..||.::|||:..|..:::..||...|:|.||.||||
  Fly   221 PAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGI 285

Human   292 VQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTT- 355
            :|.||.|||:.....|:.|...|||||..:..:|.::.||:||||||.||:.|...|.|:...:
  Fly   286 IQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEISY 350

Human   356 VGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKS---CMGLKI 417
            |.:||.||||:|:||..:|..:..:.:. ..:.|:.:.:::...|  ....|.|:.   |..:.:
  Fly   351 VDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYTDC--GGQFPSLQKRNYCNNVTL 412

Human   418 GDTVSFSIEAKVRGCP--QEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHR----CNN 476
            |..:.|.::..::..|  |.......::.....:.:.:.|.....|.||...:|.:..    |:.
  Fly   413 GKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQETPDPENEEGRFLCDY 477

Human   477 GNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQP---------VCSQRGECLCGQC 532
             .|...||:|.|..||.|:.|.|..:....:..:....:..||         |||..|:|.||.|
  Fly   478 -KGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTC 541

Human   533 VCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSN 597
            :|   |.| .||.:|||.:  |:....::    ..|.||.|:|...|:|..|||...||.|:...
  Fly   542 LC---DPG-YTGPFCECRE--CLDCDEKL----ADCFCGQCVCKYGWSGSKCNCDGDTDACVGPT 596

Human   598 GLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPD-ACTFKKECVEC---KKFDRGALHD-ENTC 657
            |.:||.||.|:|..|.|.:| ..|..||..|...: .|.|.:.||.|   :|...|...: ...|
  Fly   597 GEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEIC 660

Human   658 NRYCRDE---IESVKELKDTGKDAVNCTYKNEDDCVVR--------------FQYYEDSSGKSIL 705
            :...|.|   ...|.||.           ..:|.|:||              :|..:.|:..:|.
  Fly   661 SSLDRQETYPYNFVHELD-----------PEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFLTIQ 714

Human   706 YVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANN 770
            .|..||     ||.:.::..:....|||||..:.|....|...|.:|:|||||::..:.  ...|
  Fly   715 AVDCEP-----PDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSV--RQEN 772

Human   771 PLYKEATSTF 780
            |:|::....:
  Fly   773 PIYRDPVGRY 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ITGB3	NP_000203.2	Integrin_beta	38..461	CDD:278776	150/430 (35%)
		Involved in CX3CL1-, NRG1-, FGF1-and IGF1-binding. /evidence=ECO:0000269\|PubMed:18441324, ECO:0000269\|PubMed:19578119, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:23125415	203..210		1/6 (17%)
		CX3CL1-binding. /evidence=ECO:0000269\|PubMed:24789099	293..313		8/19 (42%)
		Cysteine-rich tandem repeats	463..629		59/178 (33%)
		Integrin_B_tail	634..717	CDD:285239	23/103 (22%)
		Integrin_b_cyt	744..786	CDD:285884	11/37 (30%)
		LIR. /evidence=ECO:0000305\|PubMed:33436497, ECO:0000305\|PubMed:33436498	777..783		0/4 (0%)
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	151/432 (35%)
		EGF_2	524..552	CDD:285248	13/31 (42%)
		Integrin_b_cyt	748..785	CDD:285884	11/37 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159899
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750