Protein Alignment ARAF and MEK1

DIOPT Version :9

• Sequence 1: NP_001243125.1
• Gene: ARAF / 369
• HGNCID: 646
• Length: 609
• Species: Homo sapiens
• Sequence 2: NP_014996.3
• Gene: MEK1 / 854533
• SGDID: S000005878
• Length: 497
• Species: Saccharomyces cerevisiae
• Alignment Length: 349
• Identity: 85/349 - (24%)
• Similarity: 145/349 - (41%)
• Gaps: 71/349 - (20%)

Human   290 DKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVF-----RGR-----WHGD-VAVKVLKV 343
            |.|.:..:|:......||:..      :.:|.|:||.|.     :.|     :|.: .|||::|:
Yeast   145 DPKLLDQMGFLREVDQWEITN------RIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKL 203

Human   344 SQPTAEQAQAFKNEMQVLRKTRHVNIL-LFMGFMTRPGFAIITQ-WCEGSSLYHHLHVAD--TRF 404
                  :...|..|.::|.:..|.||: ::..|..|.....|.| ...|..|:.:|...|  |..
Yeast   204 ------KPNKFDKEARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLAKGDCLTSM 262

Human   405 DMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFL--HEGLT-VKIGDFGLATVKTRWSGAQPL 466
            ...:.:.:..|..|.::|||.::|:|||||.:||.|  .|..| :.:.|||:|  |...|..:.:
Yeast   263 SETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIA--KDLNSNKERM 325

Human   467 EQPSGSVLWMAAEV--------------IRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGC 517
            ....|:..:.|.||              ....:...|..:.|:::.||:.:.::||..|:...|.
Yeast   326 HTVVGTPEYCAPEVGFRANRKAYQSFSRAATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGS 390

Human   518 RDQIIFMVGRGYLSPDLSK---ISSNCPKAMRRLL-SDCLK----------------FQREERPL 562
            ...||.....|.|:..|.:   :|.|....::.|| :|.:|                ..:.||..
Yeast   391 ERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWIAKHLSQLERLY 455

Human   563 FPQILATIELLQRSLPKIERSASE 586
            :.:||...|     .||:|...|:
Yeast   456 YKKILCNNE-----GPKLESINSD 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARAF	NP_001243125.1	Raf_RBD	20..91	CDD:176411
		C1_1	99..146	CDD:278556
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..210
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..293		1/2 (50%)
		STKc_A-Raf	312..576	CDD:271052	76/315 (24%)
MEK1	NP_014996.3	FHA	28..122	CDD:238017
		STKc_CAMK	160..443	CDD:270687	73/296 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910