Protein Alignment ARAF and KIN1

DIOPT Version :9

• Sequence 1: NP_001243125.1
• Gene: ARAF / 369
• HGNCID: 646
• Length: 609
• Species: Homo sapiens
• Sequence 2: NP_010407.1
• Gene: KIN1 / 851700
• SGDID: S000002529
• Length: 1064
• Species: Saccharomyces cerevisiae
• Alignment Length: 555
• Identity: 127/555 - (22%)
• Similarity: 197/555 - (35%)
• Gaps: 193/555 - (34%)

Human   158 YHSVQDLSGGSRQHEAPSNRPLNEL-----------LTPQGPSPRTQHCDPEHFPFPAPANAPLQ 211
            ||.....|.|....:...|...|.:           |...|.||:.|  ..::.|...||:
Yeast     4 YHVNTAFSMGRGNQQDDGNSESNSMHTQPSTMAPATLRMMGKSPQQQ--QQQNTPLMPPAD---- 62

Human   212 RIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSK 276
             |:..:..|.|.    |......::|.|:|               ...:|.|.:.|..|.|....
Yeast    63 -IKYANNGNSHQ----AEQKERQVELEGKS---------------RENAPKPNTTSQSRVSSSQG 107

Human   277 SPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTV--FRGRWHGDV-AV 338
            .| :|..||||.|                ||       .::.:|.||.|.|  .:.|:..:| ||
Yeast   108 MP-KQFHRKSLGD----------------WE-------FVETVGAGSMGKVKLAKHRYTNEVCAV 148

Human   339 KVLKVSQPTAEQAQAF----------KNEMQVL-----------RKTRHVNILLFMGFMTRPGFA 382
            |:  |::.|    :||          |||..||           |..|.:........:..|...
Yeast   149 KI--VNRAT----KAFLHKEQMLPPPKNEQDVLERQKKLEKEISRDKRTIREASLGQILYHPHIC 207

Human   383 IITQWCEGSSLYHHLHVADTRFDMV---QLID---------------VARQTAQGMDYLHAKNII 429
            .:.:.|   :|.:|.::.   |:.|   ||:|               .||..|..:.||||.||:
Yeast   208 RLFEMC---TLSNHFYML---FEYVSGGQLLDYIIQHGSIREHQARKFARGIASALIYLHANNIV 266

Human   430 HRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSF-QS 493
            |||||..||.:.:...:||.||||:.:   :...:.|....||:.:.|.|:::   .|||:. :.
Yeast   267 HRDLKIENIMISDSSEIKIIDFGLSNI---YDSRKQLHTFCGSLYFAAPELLK---ANPYTGPEV 325

Human   494 DVYAYGVVLYELMTGSLPY--------------------SHIGCR-------------------D 519
            ||:::||||:.|:.|.:|:                    .|:...                   .
Yeast   326 DVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQHLSIEVISLLSKMLVVDPKRRATLK 390

Human   520 QII---FMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQ---------REERPLFPQILA--TI 570
            |::   :|| ||:..|..|.:....|..:..|..:.||..         .|.|.:...|:.  |.
Yeast   391 QVVEHHWMV-RGFNGPPPSYLPKRVPLTIEMLDINVLKEMYRLEFIDDVEETRSVLVSIITDPTY 454

Human   571 ELLQR-----------------SLPKIERSASEPS 588
            .||.|                 :.|.|..|..:|:
Yeast   455 VLLSRQYWTLAAKMNAESSDNGNAPNITESFEDPT 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARAF	NP_001243125.1	Raf_RBD	20..91	CDD:176411
		C1_1	99..146	CDD:278556
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..210		12/57 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..293		12/49 (24%)
		STKc_A-Raf	312..576	CDD:271052	88/376 (23%)
KIN1	NP_010407.1	STKc_Kin1_2	118..398	CDD:270979	74/320 (23%)
		MARK_C_like	890..1062	CDD:213377

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910