Protein Alignment ARAF and Araf

DIOPT Version :9

• Sequence 1: NP_001243125.1
• Gene: ARAF / 369
• HGNCID: 646
• Length: 609
• Species: Homo sapiens
• Sequence 2: XP_038955949.1
• Gene: Araf / 64363
• RGDID: 2148
• Length: 641
• Species: Rattus norvegicus
• Alignment Length: 609
• Identity: 579/609 - (95%)
• Similarity: 588/609 - (96%)
• Gaps: 5/609 - (0%)

Human     1 MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLI 65
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    38 MEPPRGPPASGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLI 102

Human    66 KGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGY 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   103 KGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGY 167

Human   131 KFHQHCSSKVPTVCVDMSTNRQQPSRFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHC 195
            |||||||||||||||||||||:|   ||||:|||||||||.|.|||..:|||||||||||.||..
  Rat   168 KFHQHCSSKVPTVCVDMSTNRRQ---FYHSIQDLSGGSRQQEVPSNLSVNELLTPQGPSPFTQQR 229

Human   196 DPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGS 260
            |.|||.||||||.||||||||||||||||||||||||:|:|.|.||||||||| ||| ||.||||
  Rat   230 DQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTDAAG-RGG-DGAPRGS 292

Human   261 PSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFG 325
            ||||||||||||||||.||||||||||||:|||||||||||||||||||||||||||||||||||
  Rat   293 PSPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFG 357

Human   326 TVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEG 390
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
  Rat   358 TVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEG 422

Human   391 SSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLAT 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   423 SSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLAT 487

Human   456 VKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQ 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
  Rat   488 VKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQ 552

Human   521 IIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSAS 585
            |||||||||||||||||.|||||||||||:|||||||||||||||||||||||||||||||||||
  Rat   553 IIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSAS 617

Human   586 EPSLHRTQADELPACLLSAARLVP 609
            ||||||||||||||||||||||||
  Rat   618 EPSLHRTQADELPACLLSAARLVP 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARAF	NP_001243125.1	Raf_RBD	20..91	CDD:176411	70/70 (100%)
		C1_1	99..146	CDD:278556	46/46 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..210		35/46 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..293		44/49 (90%)
		STKc_A-Raf	312..576	CDD:271052	259/263 (98%)
Araf	XP_038955949.1	RBD_ARAF	56..128	CDD:340653	71/71 (100%)
		C1_A_C-Raf	133..184	CDD:410420	50/50 (100%)
		PKc_like	344..608	CDD:419665	259/263 (98%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83688960
Domainoid	1	1.000	512	1.000	Domainoid score	I6884
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1249
Inparanoid	1	1.050	1169	1.000	Inparanoid score	I4265
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49873
OrthoDB	1	1.010	-	-		D106150at7742
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		oto143335
orthoMCL	1	0.900	-	-		OOG6_100006
Panther	1	1.100	-	-	LDO	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.370