Protein Alignment ARAF and araf

DIOPT Version :9

• Sequence 1: NP_001243125.1
• Gene: ARAF / 369
• HGNCID: 646
• Length: 609
• Species: Homo sapiens
• Sequence 2: NP_991306.1
• Gene: araf / 403063
• ZFINID: ZDB-GENE-050102-2
• Length: 608
• Species: Danio rerio
• Alignment Length: 612
• Identity: 411/612 - (67%)
• Similarity: 472/612 - (77%)
• Gaps: 42/612 - (6%)

Human    16 RAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAP 80
            |..||::|||||||||||.||.|.:||||||||||||||:||||.|:||::|||.:|.|||.|.|
Zfish    20 RGGGTIRVYLPNKQRTVVNVRPGQTVYDSLDKALKVRGLSQDCCAVFRLLEGRKRLTEWDTDITP 84

Human    81 LDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCV 145
            |.||||:||||:|||||||||||||||.||:||||.||||:||||||||||||||||||||||||
Zfish    85 LVGEELLVEVLDDVPLTMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKVPTVCV 149

Human   146 DMSTNRQQPSRFYHSVQD--------LSGGSRQHEAP--SNRPLNELLTPQGPSPRTQHC----- 195
            ||.|   ...|..::.:|        .:....|.:.|  |:.|..||     ||..:..|
Zfish   150 DMDT---MTKRCVNNTEDCPAILIYPATNSISQSDLPLTSDSPGGEL-----PSSPSNFCLFIRG 206

Human   196 -DPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRG 259
             |.:          .|||.|||||||||||||..|..:.|::   :.|......|..|.:.:|:.
Zfish   207 EDGQ----------SLQRHRSTSTPNVHMVSTLEPGAAGLLE---EPFKISTVASYTGYESSPKP 258

Human   260 SPSPASVSS-GRKSPHSKSPAEQRERK-SLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTG 322
            |.||..:.| |||.|  |||:|.:||| |.:||||||...|||||.|||||.|.||.:|||||.|
Zfish   259 STSPPHLGSPGRKPP--KSPSEPKERKQSSSDDKKKVHRGGYRDSSYYWEVHPREVSMLKRIGAG 321

Human   323 SFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQW 387
            ||||||:|:||||||:|:|||::||.||.||||||||||||||||||||||||||||.|||||||
Zfish   322 SFGTVFKGKWHGDVAIKILKVTEPTPEQLQAFKNEMQVLRKTRHVNILLFMGFMTRPNFAIITQW 386

Human   388 CEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFG 452
            |||||||.||||.:|:||.::.||||||||||||||||||||||||||||||||||.||||||||
Zfish   387 CEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGWTVKIGDFG 451

Human   453 LATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGC 517
            |||||:||||:|.:||||||:||||.|||||||.|||:||||||.|||||||||:|:||||:|..
Zfish   452 LATVKSRWSGSQQVEQPSGSILWMAPEVIRMQDTNPYTFQSDVYGYGVVLYELMSGTLPYSNINN 516

Human   518 RDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIER 582
            |||||||||||||||||||:.|||||:|:||:.|||||:|:|||||||||.:||.:|..||||||
Zfish   517 RDQIIFMVGRGYLSPDLSKLYSNCPKSMKRLIIDCLKFKRDERPLFPQILVSIEQVQELLPKIER 581

Human   583 SASEPSLHR-TQADELPACLLSAARLV 608
            ||||||||| ..|::|...||...|.:
Zfish   582 SASEPSLHRAVHAEDLNPLLLHTTRFL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARAF	NP_001243125.1	Raf_RBD	20..91	CDD:176411	52/70 (74%)
		C1_1	99..146	CDD:278556	42/46 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..210		11/62 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..293		22/51 (43%)
		STKc_A-Raf	312..576	CDD:271052	216/263 (82%)
araf	NP_991306.1	Raf_RBD	24..95	CDD:176411	52/70 (74%)
		C1	103..148	CDD:237996	40/44 (91%)
		STKc_A-Raf	311..575	CDD:271052	216/263 (82%)
		Pkinase	315..566	CDD:278497	209/250 (84%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194336188
Domainoid	1	1.000	447	1.000	Domainoid score	I3624
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1249
Inparanoid	1	1.050	797	1.000	Inparanoid score	I3501
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49873
OrthoDB	1	1.010	-	-		D106150at7742
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		oto47758
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2599
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.500