DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARAF and Raf

DIOPT Version :9

Sequence 1:	NP_001243125.1	Gene:	ARAF / 369	HGNCID:	646	Length:	609	Species:	Homo sapiens
Sequence 2:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster

Alignment Length:	646	Identity:	285/646 - (44%)
Similarity:	373/646 - (57%)	Gaps:	107/646 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    11 GAEPSRAVGT--------VKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKG 67
            |::|....||        ::.:|||:|||.|.|..|:.:.|:|.||||:|.|..|.|.|.....|
  Fly   125 GSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTHSG 189

Human    68 RKTVTAWDTAIAPLDGEELIVEVLEDVPL---TMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCG 129
            |. :..|.|.|..|..||:.|.:|:..|:   ..|..:|||||||.||:.|.:.||.||.|..|.
  Fly   190 RH-IIPWHTDIGTLHVEEIFVRLLDKFPIRTHIKHQIIRKTFFSLVFCEGCRRLLFTGFYCSQCN 253

Human   130 YKFHQHCSSKVPTVC-----------------------------VDMSTNRQQPSRFYHSVQDLS 165
            ::|||.|:::||.:|                             |..:.:.:..||...|    |
  Fly   254 FRFHQRCANRVPMLCQPFPMDSYYQLLLAENPDNGVGFPGRGTAVRFNMSSRSRSRRCSS----S 314

Human   166 GGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNV---HMVSTT 227
            |.|...:.||:...|.   .||..||....|                 ||.|.|||   ::.|.|
  Fly   315 GSSSSSKPPSSSSGNH---RQGRPPRISQDD-----------------RSNSAPNVCINNIRSVT 359

Human   228 APMDSNLIQ---------LTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRE 283
            :.:..:||.         .|..|.||.|               ||.|.....: |.::|..|..:
  Fly   360 SEVQRSLIMQARPPLPHPCTDHSNSTQA---------------SPTSTLKHNR-PRARSADESNK 408

Human   284 RKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTA 348
            ...|.|.|...:|         |.:...|:.:..|||:||||||:|..|||.||||.|.|..|:.
  Fly   409 NLLLRDAKSSEEN---------WNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSP 464

Human   349 EQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVA 413
            .|.||||||:.:|:||||.|||||||.:::|..||:||||||||||.|:||::|:|.:..|||:.
  Fly   465 AQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIG 529

Human   414 RQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA 478
            ||.||||||||||||||||||||||||||.|:||||||||||.||||||.:...||:||:||||.
  Fly   530 RQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAP 594

Human   479 EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK 543
            ||||||:.|||||||||||:|:|:|||:...|||.||..:|||:||||||.|.||:|::.|:.|:
  Fly   595 EVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQ 659

Human   544 AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQA--DE---LPA 599
            |::||..||:|:..::||||..:|..:|.:.|:||||.||||||:|.::|.  ||   ||:
  Fly   660 ALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEPNLTQSQLQNDEFLYLPS 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARAF	NP_001243125.1	Raf_RBD	20..91	CDD:176411	30/78 (38%)
		C1_1	99..146	CDD:278556	24/75 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..210		11/46 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..293		12/49 (24%)
		STKc_A-Raf	312..576	CDD:271052	168/263 (64%)
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	29/70 (41%)
		C1_Raf	221..269	CDD:410361	23/47 (49%)
		STKc_Raf	435..687	CDD:270964	165/251 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	378	1.000	Domainoid score	I861
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I1004
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49873
OrthoDB	1	1.010	-	-		D129822at33208
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		otm40979
orthoMCL	1	0.900	-	-		OOG6_100006
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2599
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.010