DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARAF and pef1

DIOPT Version :9

Sequence 1:	NP_001243125.1	Gene:	ARAF / 369	HGNCID:	646	Length:	609	Species:	Homo sapiens
Sequence 2:	NP_587921.1	Gene:	pef1 / 2539366	PomBaseID:	SPCC16C4.11	Length:	288	Species:	Schizosaccharomyces pombe

Alignment Length:	310	Identity:	72/310 - (23%)
Similarity:	131/310 - (42%)	Gaps:	59/310 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   314 QLLKRIGTGSFGTVFRG--RWHGD-VAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGF 375
            |.|:::|.|::..|::|  |..|: ||:||:::.......:.|.: |:.::::.||.||:.....
pombe     4 QRLEKLGEGTYAHVYKGQNRVTGEIVALKVIRIDADEGTPSTAIR-EISLMKELRHPNIMSLSDV 67

Human   376 M-TRPGFAIITQWCEGS-SLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNI 438
            : |.....::.::.|.. ..|...:.........|:.:..:|..:|:.:.|...::|||||..|:
pombe    68 LQTENKLMLVFEYMEKDLKKYMDTYGNQGALPPSQVKNFTQQLLKGISFCHENRVLHRDLKPQNL 132

Human   439 FLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSV--LWMAAEVIRMQDPNPYSFQSDVYAYGVV 501
            .::....:|:.|||||.     |...|:...|..|  ||..|..: :.....||...|:::.|.:
pombe   133 LINSRGELKLADFGLAR-----SIGIPVNTFSNEVVTLWYRAPDV-LLGSRVYSTSIDIWSVGCI 191

Human   502 LYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDC------LKFQREER 560
            :.|:.||...::.....||::                    |..|.|.:..      :....|.:
pombe   192 MAEMATGRPLFAGSNNEDQLL--------------------KIFRLLGTPTEQSWPGISLLPEYK 236

Human   561 PLFP----QILA---------TIELLQRSLPKIERSASEPSLHRTQADEL 597
            |.||    |.||         .::||:|.|      ..:|.|..|..|.|
pombe   237 PTFPIYKAQDLAYLFPTFDPLGLDLLRRML------RLQPELRTTGQDAL 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARAF	NP_001243125.1	Raf_RBD	20..91	CDD:176411
		C1_1	99..146	CDD:278556
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..210
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..293
		STKc_A-Raf	312..576	CDD:271052	65/287 (23%)
pef1	NP_587921.1	PKc_like	2..285	CDD:304357	72/310 (23%)
pef1	NP_587921.1	PLN00009	3..285	CDD:177649	72/310 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910