DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARAF and lin-45

DIOPT Version :9

Sequence 1:	NP_001243125.1	Gene:	ARAF / 369	HGNCID:	646	Length:	609	Species:	Homo sapiens
Sequence 2:	NP_001379593.1	Gene:	lin-45 / 177436	WormBaseID:	WBGene00003030	Length:	855	Species:	Caenorhabditis elegans

Alignment Length:	692	Identity:	267/692 - (38%)
Similarity:	367/692 - (53%)	Gaps:	138/692 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    21 VKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRK-----TVTAWDTAIAP 80
            :.|:||..|.:.|.||.|.:..|::.|.||.|.:....|.|......::     ::|..:.| :.
Worm   129 IMVHLPFDQHSRVEVRPGETARDAISKLLKKRNITPQLCHVNASSDPKQESIELSLTMEEIA-SR 192

Human    81 LDGEELIV--EVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF-HGFRCQTCGYKFHQHCSSKVPT 142
            |.|.||.|  |.|..|....|..||:||.....||.|...:: .||||:.|.:||||.|||..|.
Worm   193 LPGNELWVHSEYLNTVSSIKHAIVRRTFIPPKSCDVCNNPIWMMGFRCEFCQFKFHQRCSSFAPL 257

Human   143 VCVDMSTNRQQPSRFYHSVQDLSGGSRQHEAPSNRPLNEL----LTP---QGP--SPRTQHCD-- 196
            .| |:   .|...:....|::|.|.:.|.|.| :|.:.|:    |.|   |.|  :|.:.|.|
Worm   258 YC-DL---LQSVPKNEDLVKELFGIASQVEGP-DRSVAEIVLANLAPTSGQSPAATPDSSHPDLT 317

Human   197 ----------------PEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQL-------- 237
                            |::.......:.|..|.||:|.||::.::..|.:..|...|
Worm   318 SIKRTGGVKRHPMAVSPQNETSQLSPSGPYPRDRSSSAPNINAINDEATVQHNQRILDALEAQRL 382

Human   238 -------TGQSFSTDA------------AGSRGGS-----DGTPRGSPSPASVSSG--------- 269
                   ||...||.|            :|:|...     |.||.||.||:|..|.
Worm   383 EEESRDKTGSLLSTQARHRPHFQSGHILSGARMNRLHPLVDCTPLGSNSPSSTCSSPPGGLIGQP 447

Human   270 --RKSPH--------------------------------------SKSPAEQRERKSLADDKKKV 294
              .:||:                                      |:||.|:.:    |...:..
Worm   448 TLGQSPNVSGSTTSSLVAAHLHTLPLTPPQSAPPQKISPGFFRNRSRSPGERLD----AQRPRPP 508

Human   295 KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQ 359
            :...:.|    ||:.|:|..:..::|:||||||:||.:.|.||:|.|.|..||..|..|||||:.
Worm   509 QKPHHED----WEILPNEFIIQYKVGSGSFGTVYRGEFFGTVAIKKLNVVDPTPSQMAAFKNEVA 569

Human   360 VLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTR--FDMVQLIDVARQTAQGMDY 422
            ||:||||:|:|||||::..|..|||||||||||||.|:||.:.|  |:|..:||:.:|.:.||:|
Worm   570 VLKKTRHLNVLLFMGWVREPEIAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNY 634

Human   423 LHAKNIIHRDLKSNNIFLHEGL-TVKIGDFGLATVKTRW--SGAQPLEQPSGSVLWMAAEVIRMQ 484
            ||:|||||||||:|||||.:.: ||||||||||||||:|  :|.|..:||:||:||||.||||||
Worm   635 LHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQ 699

Human   485 DPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLL 549
            |.|||:.|||||::|:.:||:::..||||:|..||||:||||||||.||.|||..:.||:|.:|.
Worm   700 DDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKLY 764

Human   550 SDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPS-LH 590
            .:|:.|.|.|||:|.::|.  .|....|||:.||.|.|: ||
Worm   765 DNCIMFDRNERPVFGEVLE--RLRDIILPKLTRSQSAPNVLH 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARAF	NP_001243125.1	Raf_RBD	20..91	CDD:176411	23/76 (30%)
		C1_1	99..146	CDD:278556	22/47 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..210		15/73 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..293		21/115 (18%)
		STKc_A-Raf	312..576	CDD:271052	156/268 (58%)
lin-45	NP_001379593.1	RBD	128..203	CDD:128731	22/74 (30%)
		C1_Raf	211..260	CDD:410361	22/49 (45%)
		STKc_Raf	529..786	CDD:270964	154/258 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I636
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1045
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129822at33208
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		otm15683
orthoMCL	1	0.900	-	-		OOG6_100006
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2599
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.000