Protein Alignment ARAF and Araf

DIOPT Version :9

• Sequence 1: NP_001243125.1
• Gene: ARAF / 369
• HGNCID: 646
• Length: 609
• Species: Homo sapiens
• Sequence 2: XP_011245731.2
• Gene: Araf / 11836
• MGIID: 88065
• Length: 674
• Species: Mus musculus
• Alignment Length: 609
• Identity: 577/609 - (94%)
• Similarity: 588/609 - (96%)
• Gaps: 5/609 - (0%)

Human     1 MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLI 65
            ||||||||.:||||||||||||||||||||||||||:||||||||||||||||||||||||||||
Mouse    71 MEPPRGPPVSGAEPSRAVGTVKVYLPNKQRTVVTVREGMSVYDSLDKALKVRGLNQDCCVVYRLI 135

Human    66 KGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGY 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   136 KGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGY 200

Human   131 KFHQHCSSKVPTVCVDMSTNRQQPSRFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHC 195
            |||||||||||||||||||||:|   ||||:|||||||||.|||||..:|||||||||||.||..
Mouse   201 KFHQHCSSKVPTVCVDMSTNRRQ---FYHSIQDLSGGSRQQEAPSNLSVNELLTPQGPSPFTQQR 262

Human   196 DPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGS 260
            |.|||.||||||.||||||||||||||||||||||||:|:|.|.||||||||| ||| ||.||||
Mouse   263 DQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTDAAG-RGG-DGAPRGS 325

Human   261 PSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFG 325
            ||||||||||||||||.|:||||||||||:|||||||||||||||||||||||||||||||||||
Mouse   326 PSPASVSSGRKSPHSKLPSEQRERKSLADEKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFG 390

Human   326 TVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEG 390
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 TVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEG 455

Human   391 SSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLAT 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 SSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLAT 520

Human   456 VKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQ 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
Mouse   521 VKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQ 585

Human   521 IIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSAS 585
            |||||||||||||||||.|||||||||||:|||||||||||||||||||||||||||||||||||
Mouse   586 IIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSAS 650

Human   586 EPSLHRTQADELPACLLSAARLVP 609
            ||||||||||||||||||||||||
Mouse   651 EPSLHRTQADELPACLLSAARLVP 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARAF	NP_001243125.1	Raf_RBD	20..91	CDD:176411	69/70 (99%)
		C1_1	99..146	CDD:278556	46/46 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..210		36/46 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..293		43/49 (88%)
		STKc_A-Raf	312..576	CDD:271052	259/263 (98%)
Araf	XP_011245731.2	RBD_ARAF	89..161	CDD:340653	70/71 (99%)
		C1_1	169..214	CDD:365894	44/44 (100%)
		PKc_like	377..641	CDD:389743	259/263 (98%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83965387
Domainoid	1	1.000	512	1.000	Domainoid score	I7304
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1249
Inparanoid	1	1.050	1166	1.000	Inparanoid score	I4585
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49873
OrthoDB	1	1.010	-	-		D106150at7742
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		oto127296
orthoMCL	1	0.900	-	-		OOG6_100006
Panther	1	1.100	-	-	LDO	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2599
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.400