Protein Alignment ARAF and araf

DIOPT Version :9

• Sequence 1: NP_001243125.1
• Gene: ARAF / 369
• HGNCID: 646
• Length: 609
• Species: Homo sapiens
• Sequence 2: XP_031746913.1
• Gene: araf / 100495479
• XenbaseID: XB-GENE-5755831
• Length: 644
• Species: Xenopus tropicalis
• Alignment Length: 616
• Identity: 431/616 - (69%)
• Similarity: 495/616 - (80%)
• Gaps: 33/616 - (5%)

Human     3 PPRG------PPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVV 61
            |.||      |.|.|    ::.|||||||||:|||||.||.||:||||||||||||||:|:||.|
 Frog    52 PSRGASVSEYPHAEG----KSGGTVKVYLPNQQRTVVNVRPGMTVYDSLDKALKVRGLSQECCAV 112

Human    62 YRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQ 126
            ||||:|||.:|.|:|.|.||.||||:||||.||||:||||||||.|:||||||||||||||||||
 Frog   113 YRLIQGRKALTDWETDITPLVGEELMVEVLADVPLSMHNFVRKTHFTLAFCDFCLKFLFHGFRCQ 177

Human   127 TCGYKFHQHCSSKVPTVCVDMSTNRQQPSRFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPR 191
            ||||||||||||||||.||||:...:..:..  |.||...   .:|.|:   ::..|:||.||||
 Frog   178 TCGYKFHQHCSSKVPTACVDMAKLPKPLTPL--SYQDFQS---YYEHPT---VHLPLSPQPPSPR 234

Human   192 TQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGT 256
            |||.....|.||.... ||||.|||||||||:.|||.|:|:::|:...:|.:.           |
 Frog   235 TQHPGSASFSFPGEGQ-PLQRHRSTSTPNVHIDSTTGPVDNSIIEEALRSAAV-----------T 287

Human   257 PRGSPSPASVSSGRKSPHSKSPAE-QRERK-SLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRI 319
            |...|..::...|.|||.:|||:| .|||| |.:|:|||||.||||||.|||||..|||.:||||
 Frog   288 PVDGPPKSAQPLGSKSPQTKSPSETTRERKTSASDEKKKVKQLGYRDSSYYWEVNSSEVIILKRI 352

Human   320 GTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAII 384
            ||||||||:||:||||||||:|||:.||:||.||||||||||||||||||||||||||||.||||
 Frog   353 GTGSFGTVYRGKWHGDVAVKILKVTNPTSEQIQAFKNEMQVLRKTRHVNILLFMGFMTRPQFAII 417

Human   385 TQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIG 449
            ||||||||||.||||.:||||:.||||:|||||||||||||||||||||||||||||||||||||
 Frog   418 TQWCEGSSLYRHLHVIETRFDIFQLIDIARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIG 482

Human   450 DFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSH 514
            |||||||||||||:|.:||||||:||||.||||||:.:|||.|||||||||||||||.|.|||::
 Frog   483 DFGLATVKTRWSGSQQVEQPSGSILWMAPEVIRMQESSPYSSQSDVYAYGVVLYELMAGLLPYAN 547

Human   515 IGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPK 579
            |..|||||||||||||:|||||:|:||||||:|||.:||||:|||||||||||::||||||:|||
 Frog   548 INNRDQIIFMVGRGYLTPDLSKVSNNCPKAMKRLLVNCLKFKREERPLFPQILSSIELLQRALPK 612

Human   580 IERSASEPSLHR-TQADELPACLLSAARLVP 609
            |||||||||||| ..:::|...|::..||||
 Frog   613 IERSASEPSLHRAVNSEDLNPFLINTLRLVP 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARAF	NP_001243125.1	Raf_RBD	20..91	CDD:176411	54/70 (77%)
		C1_1	99..146	CDD:278556	43/46 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..210		16/46 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..293		18/51 (35%)
		STKc_A-Raf	312..576	CDD:271052	223/263 (85%)
araf	XP_031746913.1	RBD_ARAF	70..142	CDD:340653	55/71 (77%)
		C1_A_C-Raf	147..198	CDD:410420	46/50 (92%)
		PKc_like	345..609	CDD:419665	223/263 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	452	1.000	Domainoid score	I4696
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	831	1.000	Inparanoid score	I4193
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129822at33208
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		oto158965
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060