Protein Alignment CG15614 and sprr-2

DIOPT Version :10

• Sequence 1: NP_611168.2
• Gene: CG15614 / 36899
• FlyBaseID: FBgn0034168
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_510455.2
• Gene: sprr-2 / 181575
• WormBaseID: WBGene00009629
• Length: 451
• Species: Caenorhabditis elegans
• Alignment Length: 1314
• Identity: 263/1314 - (20%)
• Similarity: 423/1314 - (32%)
• Gaps: 469/1314 - (35%)

  Fly     3 GSSAGLSVAIWSG--------SSGCSLVFVTTLDGKMSAL--DMLNGGAERWSIQTGPGPLLSSS 57
            |..|.|||:.::|        :||..|.|.|.|...:|::  |:|.|...  |......|.||..
 Worm   422 GGQASLSVSTYTGLIRLLSTCASGSPLGFRTLLLLGISSILKDILLGSGV--SANASVSPALSRP 484

  Fly    58 IHRL-ELTNNGKWVRMIPSLGGSLYKFDGDSIEPIPFSAEDLLKSSFKFSDDLVISGGKE----- 116
            ..:: |:.|...  .::|.|        .:.:..:|.|...|:|.|.:.......||.:|
 Worm   485 ADQIYEIVNLAN--ELLPPL--------PEGVISLPTSTNALVKGSCQKKSSPSTSGKQEDILKI 539

  Fly   117 -------------------------TRSYGVSMQ----------TGQLIYVCTMQGCKNATELAM 146
                                     .:.||.|:.          .|:|:|.       :::|:..
 Worm   540 SPREKLLGDQPELLQQFGLDLLPVLVQIYGSSVNGTIRHKCLSVIGKLMYF-------SSSEMIQ 597

  Fly   147 EMAADGKYGPPEDGAGTLDPMQEDVLVIRRQTQTVRAVESRTGSERWNFSIGHHEVEKMSNEDCR 211
            .:..|....  ...||.|......|||...|...:.                   :||:.
 Worm   598 SLIGDTNIS--SFLAGVLAWKDPQVLVPALQVAEIL-------------------MEKLP----- 636

  Fly   212 GGKERREVDPVILDLDLRVIIPEGVICAVRKSAPGEIVWRHKFEVPIVSAWRSSGKTNDQLVGVD 276
                         :...:|.:.|||:.||.:..   :|.:.....|       :.|.||.:.|..
 Worm   637 -------------ETFSKVFVREGVVHAVDQLV---LVGKPSHASP-------TDKDNDCVPGSA 678

  Fly   277 IFDR-TDWMWNGNVDDSESGDRPPLINP-SLYIGMHDKQLYIQESAAMIEEREEKMQQLALLTDE 339
            ...| .....|.|.|.::| :.|.  || ||.||.:...|....::.|:.|           |..
 Worm   679 RSRRYRRRSSNANSDGNQS-EEPK--NPASLTIGANHNSLDTPTASFMLRE-----------TVS 729

  Fly   340 SKLPAIPWKPLPASRGIAGLLTDGDNQFQLVKDDEDDAGESTAIARSVLYASNY----------- 393
            |...|...|..|:..|                  :.|.|    :...:|:..|.
 Worm   730 SCAKAFKDKYFPSDGG------------------DVDVG----VTDDLLHLKNLCTKLTAGIDDH 772

  Fly   394 -INGNG-------FFLVYDTERDDEQCG-----HGEDESNGDNNSTKFGHDGSHDHGEDMDTMFD 445
             :.|.|       |...:...:::...|     .|| .|.||..|| |...||
 Worm   773 KVKGKGKSKASGPFLGDFSASKEEYLIGVISEILGE-ISKGDGVST-FEFIGS------------ 823

  Fly   446 APVKVII--VSMWYWWKEILIISITTALILNMMLKLRLE---------------------KPPVM 487
            ..|..::  .|..|:.||    .|:.   ||:. |||.|                     .||:.
 Worm   824 GVVAALLNYFSCGYFSKE----KISE---LNLP-KLRQEGLRRFKAFLEVALPFDGNEGKVPPMT 880

  Fly   488 VVVERKVTVPIPTAVEAVEEFPPAIRMTATRSYSESSS-SNGPPALVDNYTSRFRDDFDLVQCLG 551
            |::::     :..|:.::|.| |.:....:||.|.|:. |:|..||....
 Worm   881 VLIQK-----LQNALSSLERF-PVVLSHPSRSLSGSARLSSGLSALAHPL--------------- 924

  Fly   552 KGGFGVVFEVRNKLDDCRYAIKRVVLPNKQESKDRVMREVKTLAHCEHQNIVRYFHAWIETPPPG 616
                        ||..||            .|.::.:|:..:       |||      :..|...
 Worm   925 ------------KLRLCR------------ASGEKTLRDYSS-------NIV------LIDPLAS 952

  Fly   617 WQERHDREW--IER--NCLSTSIDI-ETPTDTCPPLPGVA--ASATTASSFAVGMKNSRLQASSI 674
            .....:..|  ::|  :.|..:..| .|...|.|...||:  :|:|.||:   ..::|....|:|
 Worm   953 LAAVEEFLWPRVQRSESALKPAAPIGNTEPGTLPSGAGVSSPSSSTPAST---TRRHSSRSRSAI 1014

  Fly   675 QSNLWMPQFPAANFSFSNGIGDGLSLKRYEQSD----SCSFIEFRAEGEQDGQ--PARDDETSSS 733
            .......:.|......|:..|.|..:.:..|:|    :.|..:.||..::|.|  ||..|.:|..
 Worm  1015 NIGDTSKKDPVHEKGTSSSKGKGKGVMKPAQADKGPQTRSNAQKRAVLDKDTQMKPASGDSSSED 1079

  Fly   734 SESE------------SEDEASEVQSNGKHRWNDEPEDDSL---------DIVFKEPSGSEGI-- 775
            .|.|            .||:.|:.:.:.    |::..||||         |:...:....:|:
 Worm  1080 EELEISPVDIDDALVIEEDDISDDEDDD----NEDVLDDSLPMCTPDKVHDVKLADSVDDDGLAT 1140

  Fly   776 -------SSGGAVAQQHAVAIDVSSSPEGRSH---------PAAMK--DARNGPNVEQQQQQQKP 822
                   :|||......|.|.|...:..|.|:         .|||.  .|.:|..:...
 Worm  1141 SGRQMNPASGGTSGAAAARASDSIDTGIGNSYGSRGALSFAAAAMAGLGAASGRGIRGS------ 1199

  Fly   823 NPFRKTHRRPLSLDLTSTMRSSRDPCTL---PSGTDQSKASSAQSNKIYLYIQMQLC------HK 878
               |..|.|.|:       |||.:|..|   .:|...|:..:     ||..:|.||.      .:
 Worm  1200 ---RDLHGRTLN-------RSSDEPSKLIFTAAGKQLSRHLT-----IYQAVQRQLMLDEDDDDR 1249

  Fly   879 QSLKEWLSLNGFPARRDKIVPIFEQIVAGVEYVHLKGLIHRDLKPSNIFFSLDGRIKIGDFGLVT 943
            ....:.:|.:|  :|.:.|..|..|                  :|.    |...|:.:|.....|
 Worm  1250 FGGSDLVSSDG--SRFNDIYTIMYQ------------------RPD----SQVNRLSVGGASSTT 1290

  Fly   944 DSSDLQYDSENNMPTMVPNRHTRQVGTQLYMSPEQLKG-LPYDYKV--DIYSLGLILFELLVSFG 1005
            .|...:..:.|:......:|.:        :....|:| ||.|.:.  ..|:: |.|..:|..
 Worm  1291 PSKSTKSATTNSSVESQSHRAS--------LLDSILQGELPCDLEKSNSTYNV-LALLRVLEG-- 1344

  Fly  1006 TEMERICTLKNVRKSKFPDNFEEDHECEFKLLSLMLSEAPNKRPTTFGIKAHPPFKRIPSNKSTN 1070
              :.::|  ..:|.....|.|.|.     |:.||      :...||   .|..|.....::|.|.
 Worm  1345 --LNQLC--PRLRAQTLSDRFAEG-----KITSL------DDLSTT---AAKVPLDEFVNSKLTP 1391

  Fly  1071 SLG-VVDETLVVDSGPGSTNGSFESEDGDEWHFEL--------PPRRKDSRTYSTS--------- 1117
            .|. .:.:.|.:.|      ||..|     |.::|        |.:.:....|||:
 Worm  1392 KLARQIQDALALCS------GSLPS-----WCYQLTRACPFLFPFQTRRQYFYSTAFGLSRALNR 1445

  Fly  1118 --------GSGSGN 1123
                    ||||.|
 Worm  1446 LQQQQGADGSGSTN 1459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15614	NP_611168.2	7tmA_FMRFamide_R-like	40..338	CDD:410630	60/340 (18%)
		TM helix 1	41..67	CDD:410630	6/26 (23%)
		TM helix 2	73..98	CDD:410630	4/24 (17%)
		TM helix 3	112..142	CDD:410630	9/69 (13%)
		TM helix 4	157..177	CDD:410630	6/19 (32%)
		TM helix 5	200..225	CDD:410630	2/24 (8%)
		TM helix 6	257..293	CDD:410630	9/36 (25%)
		TM helix 7	306..331	CDD:410630	5/24 (21%)
sprr-2	NP_510455.2	7tmA_FMRFamide_R-like	59..376	CDD:410630
		TM helix 1	60..86	CDD:410630
		TM helix 2	92..117	CDD:410630
		TM helix 3	138..168	CDD:410630
		TM helix 4	180..200	CDD:410630
		TM helix 5	242..267	CDD:410630
		TM helix 6	295..325	CDD:410630
		TM helix 7	344..369	CDD:410630