Protein Alignment inaC and LATS1

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_016866963.1
• Gene: LATS1 / 9113
• HGNCID: 6514
• Length: 1163
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 158/602 - (26%)
• Similarity: 248/602 - (41%)
• Gaps: 163/602 - (27%)

  Fly   200 YVELKGNNLKV--DIKEAANLIPMDTNGFSDPYIAVQMHPDRS----GRTKKKTKTIQKNLNPVF 258
            :.|...:|:.|  .:.||.|.     .|...||....:|.:.|    ....|.:|..|.:|....
Human   532 FPEGTASNVTVMPPVAEAPNY-----QGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKED 591

  Fly   259 NETFTFE-LQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGW----YKFLSQVEG 318
            ....::| :...|::|:.:.......|.::.|         ||.::..:..:    :||..:...
Human   592 ESEKSYENVDSGDKEKKQITTSPITVRKNKKD---------EERRESRIQSYSPQAFKFFMEQHV 647

  Fly   319 EHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSK------RDMIRAADFNF---- 373
            |:.             |:.   |.:|.:.|::::|:.|...:|:      |.|:...:.|:
Human   648 ENV-------------LKS---HQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLK 696

  Fly   374 -----------VKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSG 427
                       :|.:|.|:||:|.||.:..|..|||.|.|||..::..:.:.....|:.|||.:.
Human   697 RAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEAD 761

  Fly   428 RPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDII 492
            . .::|.::..||..|.|:|||:|..|||:|..:.:.|.|.||:|.||..|:..|:..:|:...|
Human   762 N-EWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFI 825

  Fly   493 YRDLKLDNILLDGEGHVKLVDFGLS------------KEGVTERQTTRTF--------------- 530
            :||:|.||||:|.:||:||.||||.            :.|...||.:..|
Human   826 HRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDR 890

  Fly   531 --------------C------GTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPF----- 570
                          |      |||||:|||::....|:...||||.||:|||.:.||.||
Human   891 LKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTP 955

  Fly   571 -------------------EGDDE----TTVFR--------NIKDKKAVFPK-HFSVEAMDIITS 603
                               ||...    |..|.        |.:....:.|: ..|.||.|:|..
Human   956 LETQMKPGMVAHTCNPSALEGHSRKNTGTQEFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIK 1020

  Fly   604 FLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKT 668
             |.:.|.:||  |:....||..||||:.:|: .::..:......|.|.|..|.||||.
Human  1021 -LCRGPEDRL--GKNGADEIKAHPFFKTIDF-SSDLRQQSASYIPKITHPTDTSNFDP------- 1074

  Fly   669 DLTPTDKLFMMNLDQND 685
              ...|||:.   |.|:
Human  1075 --VDPDKLWS---DDNE 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342
		C1	137..190	CDD:412127
		C2_PKC_alpha_gamma	194..324	CDD:175992	25/134 (19%)
		STKc_PKC	375..692	CDD:270722	123/395 (31%)
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580
		PRK10263	<448..>596	CDD:236669	15/68 (22%)
		MobB_LATS1	629..704	CDD:439273	13/90 (14%)
		Protein Kinases, catalytic domain	703..1117	CDD:473864	123/401 (31%)