DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and PKC1

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_009445.2	Gene:	PKC1 / 852169	SGDID:	S000000201	Length:	1151	Species:	Saccharomyces cerevisiae

Alignment Length:	767	Identity:	240/767 - (31%)
Similarity:	351/767 - (45%)	Gaps:	150/767 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RKGAMKRKGLEMV--NGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVF 119
            |.||:..:..|:.  :||.|..:.|.|...|.:|.||:   ...||||::|:|..|:||...||.
Yeast   398 RHGAIINRKEEIFEQHGHHFVQKSFYNIMCCAYCGDFL---RYTGFQCQDCKFLCHKKCYTNVVT 459

  Fly   120 KCPGK-DTDFDADCAK----VKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQ 179
            ||..| .||.|.|.||    :.|.::.|:.....:|..||.:|....|:..||..|.:..|..|.
Yeast   460 KCIAKTSTDTDPDEAKLNHRIPHRFLPTSNRGTKWCCHCGYILPWGRHKVRKCSECGIMCHAQCA 524

  Fly   180 ETVPPMCGADISEVRGKLLLYVE------------------------LKGNNLKVD-IKEAAN-- 217
            ..||..||..: |:..|:|..::                        ..|::|... :.|.||
Yeast   525 HLVPDFCGMSM-EMANKILKTIQDTKRNQEKKKRTVPSAQLGSSIGTANGSDLSPSKLAERANAP 588

  Fly   218 LIPM--------------------DTNGFSDPYIAVQMHPDRSGRTKKKTKTI------------ 250
            |.|.                    ..:...|..|::|.|    || :|..|.|
Yeast   589 LPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRISLQTH----GR-EKLNKFIDENEAYLNFTEG 648

  Fly   251 ----------QKNLNPVFN------------ETFTFELQPQDRDKRLLIEVW------------- 280
                      :|.|:|..|            .:.|:|  .:|...|..:|:|
Yeast   649 AQQTAEFSSPEKTLDPTSNRRSLGLTDLSIEHSQTWE--SKDDLMRDELELWKAQREEMELEIKQ 711

  Fly   281 ----------------------DWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNI 323
                                  ||:  ::|||..: ..:::.....|.........|:|.:|.:
Yeast   712 DSGEIQEDLEVDHIDLETKQKLDWE--NKNDFREA-DLTIDSTHTNPFRDMNSETFQIEQDHAS- 772

  Fly   324 PCVDAFNDIARLRDEVRHDRR------PNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSF 382
              .:...:...|.....|..|      |.:.:...:.......:||..:...:|..:||:|||:|
Yeast   773 --KEVLQETVSLAPTSTHASRTTDQQSPQKSQTSTSAKHKKRAAKRRKVSLDNFVLLKVLGKGNF 835

  Fly   383 GKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKI--LALSGRPPFLVSMHSCFQTMDRL 445
            |||:|::.:.||.|.|:|||:||.|||..|:|....|||:  ||...:.|||.:::..|||.:|:
Yeast   836 GKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRI 900

  Fly   446 FFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVK 510
            :|.||:..|||||:|:|.. |.....|.|||.||.:||.:.|:..:|||||||:||||..|||:|
Yeast   901 YFAMEFIGGGDLMWHVQNQ-RLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIK 964

  Fly   511 LVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDE 575
            :.|:||.|:.:.....|.||||||.:|||||:....|:.|.|||:|||||::.:..|:||.||||
Yeast   965 IADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPFSGDDE 1029

  Fly   576 TTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEAC 640
            ..||..|...:.::|...:.|.:.|....|||.|..|||||.....|:...|||||:::|.....
Yeast  1030 DEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGAGPRDADEVMEEPFFRNINFDDILNL 1094

  Fly   641 EMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFM 692
            .::||..|.||..:|.|.|:..||.....|||...: :....|.:|.|||||
Yeast  1095 RVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTPLPSV-LTTSQQEEFRGFSFM 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	21/51 (41%)
		C1_1	137..189	CDD:278556	16/51 (31%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	37/245 (15%)
		S_TKc	371..629	CDD:214567	122/259 (47%)
		STKc_PKC	375..692	CDD:270722	144/318 (45%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010
		C2_fungal_Pkc1p	211..319	CDD:176071
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	22/53 (42%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	16/58 (28%)
		STKc_PKC	828..1145	CDD:270722	144/318 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I225
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm46471
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060