DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and prkcd

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_002934267.1	Gene:	prkcd / 733756	XenbaseID:	XB-GENE-478663	Length:	683	Species:	Xenopus tropicalis

Alignment Length:	651	Identity:	239/651 - (36%)
Similarity:	337/651 - (51%)	Gaps:	124/651 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVV 118
            || |:||:|:..:..:..|.|...||..||:|..|:||:||..|||::|.:|...||:||.:.::
Frog   141 NR-RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCRDFVWGLNKQGYKCRQCNAAIHKKCIEMII 204

  Fly   119 FKCPG-----KDTDFDADCAKV--KHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHH 176
            .:|.|     :||.|..:...:  .|.:....|.:|||||.||.||.|:..||:||:.|.:||||
Frog   205 GRCTGTAANSRDTMFQKERFNIDMPHRFKVYNYKSPTFCDHCGSLLWGLVKQGLKCDECAMNVHH 269

  Fly   177 ACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSG 241
            .||..|..:||     :..|||              .||.|.:.|.::             .|..
Frog   270 KCQNKVANLCG-----INQKLL--------------AEALNQVSMKSS-------------SRKS 302

  Fly   242 RTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPV 306
            .:......|.:.:||                                              |.|
Frog   303 DSGLDNIAIYQGVNP----------------------------------------------KTP- 320

  Fly   307 DGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPH-NMSKRDMIRAAD 370
                           .:|..||.:               |:..|:.....|| ::|....::..:
Frog   321 ---------------GLPMPDATD---------------NQYDRLWEGSSPHPHISLSSRLKIDN 355

  Fly   371 FNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSM 435
            |.|.||:||||||||||||.:|..|.:|:|.|:|||::..||:|..|.||::|||:...|||..:
Frog   356 FVFHKVLGKGSFGKVLLAELKGKGEYFAIKALKKDVVLIDDDVECTMVEKRVLALAWENPFLTHI 420

  Fly   436 HSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDN 500
            :..|||.:.||||||:..|||||:|:|..|||....|.|||.|:...|.|||.:.||||||||||
Frog   421 YCSFQTKEHLFFVMEFLNGGDLMFHIQDKGRFDLYRATFYASEIICGLQFLHSKGIIYRDLKLDN 485

  Fly   501 ILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMA 565
            ::||.:||:|:.|||:.||.|.......||||||:|:||||:....|:.:.|||||||||:|.:.
Frog   486 VMLDKDGHIKIADFGMCKENVYGDNKASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLI 550

  Fly   566 GQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLG-AGRYARQEITTHPFF 629
            ||:||.||||..:|.:|:.....:|:..:.|:.||:.....::|..||| .|     .|..||||
Frog   551 GQSPFHGDDEDELFESIRQDTPHYPRWITKESKDILERLFEREPTKRLGVVG-----NIKVHPFF 610

  Fly   630 RNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNP 694
            :.::|...|..|:|||.||.:|...|.||||..|..||..|:.:||..:.::||:.|.||||:||
Frog   611 KTINWTALERRELEPPFKPKVKSPSDYSNFDREFLSEKPRLSFSDKNLIDSMDQSAFHGFSFINP 675

  Fly   695 E 695
            :
Frog   676 K 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	23/56 (41%)
		C1_1	137..189	CDD:278556	26/51 (51%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	13/129 (10%)
		S_TKc	371..629	CDD:214567	129/258 (50%)
		STKc_PKC	375..692	CDD:270722	155/317 (49%)
prkcd	XP_002934267.1	C1_1	158..207	CDD:365894	21/48 (44%)
		C1_1	230..280	CDD:365894	24/49 (49%)
		STKc_nPKC_delta	360..675	CDD:173710	156/319 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910