DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and pkn1a

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_005160107.3	Gene:	pkn1a / 560840	ZFINID:	ZDB-GENE-061207-17	Length:	967	Species:	Danio rerio

Alignment Length:	520	Identity:	177/520 - (34%)
Similarity:	281/520 - (54%)	Gaps:	57/520 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 KLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNE 260
            ||..:::.:.:.::::::....|:...|  |.:|.|      :|..|.|::.....|.....|.
Zfish   480 KLEDFLDNQKHKVQLELEPQGLLLAEVT--FFNPVI------ERVPRLKRQKNVFSKQQGKAFL- 535

  Fly   261 TFTFELQPQDRDKRLLIEVWDWDRTSRN-----DFMGSFSFSLEELQKEPVDGWYKFLSQVE--G 318
                      |.:::.:::..:.|..||     :..|::|.:...||...:        .||  .
Zfish   536 ----------RARQMNVDIGTFVRLLRNAIPTVNNTGTYSPNAHTLQTGEI--------SVEKLS 582

  Fly   319 EHYNIPC-VDAFNDIARLRDEVRHDRRPNEKRRMDNKDMP--------HNMS---KRDMIRAADF 371
            ..::.|. ||       :|.||.....|..:...:....|        |::|   |:..:...||
Zfish   583 LDFDSPMKVD-------IRREVTDISTPERQPSTEPLSAPDVTTPIRTHSLSSKQKKTSLSLQDF 640

  Fly   372 NFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKIL-ALSG-RPPFLVS 434
            ..:.|:|:|.||||||||.:.:..:||:|.|:|..|:..|::|..|.||:|. |::| :.||||:
Zfish   641 RLIAVLGRGHFGKVLLAEYKKSGSMYAIKALKKGDIVARDEVESLMCEKRIFEAVNGAQHPFLVN 705

  Fly   435 MHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLD 499
            :.:||||.:.:.|||||..|||||.|:.. ..|.|..|:||:..|.:.|.|||:..|:|||||||
Zfish   706 LFACFQTPEHVCFVMEYTAGGDLMMHIHA-DVFTEPRAVFYSACVVLGLQFLHDNKIVYRDLKLD 769

  Fly   500 NILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFM 564
            |:|||.||:||:.||||.|||:.....|.||||||.::|||:::...|:.|.|||..|||::|.:
Zfish   770 NLLLDTEGYVKIADFGLCKEGMGFGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEML 834

  Fly   565 AGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFF 629
            .|::||.||||..||.:|.:.:..:|:..|.||:.|:...|.:.|..|||:.....:::...|||
Zfish   835 VGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSEKDAEDVKKQPFF 899

  Fly   630 RNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLT-PTDKLFMMNLDQNDFIGFSFMN 693
            ||:||:.....::.||..|.|..::|:||||:.||.|...|| |.:...:...||:.|..|.:::
Zfish   900 RNMDWEALLLRKLPPPFIPSIGGKEDVSNFDEEFTTEAPTLTPPREPRVLSRKDQDSFRDFDYVS 964

Fly 694 693
Zfish 965 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992	22/134 (16%)
		S_TKc	371..629	CDD:214567	118/259 (46%)
		STKc_PKC	375..692	CDD:270722	142/319 (45%)
pkn1a	XP_005160107.3	HR1_PKN_1	71..136	CDD:212012
		HR1_PKN1_2	156..233	CDD:212020
		HR1	237..310	CDD:320753
		C2	421..508	CDD:326325	4/29 (14%)
		STKc_PKN	640..965	CDD:270741	143/326 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840