DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and PRKCQ

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_005252553.1	Gene:	PRKCQ / 5588	HGNCID:	9410	Length:	740	Species:	Homo sapiens

Alignment Length:	668	Identity:	236/668 - (35%)
Similarity:	336/668 - (50%)	Gaps:	143/668 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKC 121
            |:||:|:..:..|..|.|...||..||:|..|.:|:||..|||:||.:|...||:||...|:.||
Human   179 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 243

  Fly   122 PG-----KDTDFDADCAKV--KHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQ 179
            .|     ::|.|..:..|:  .|.:....|.:||||:.||.||.|:|.||:||:.|.:||||.||
Human   244 TGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQ 308

  Fly   180 ETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTK 244
            ..|..:||     :..||:              .||..:|                ...:..|..
Human   309 TKVANLCG-----INQKLM--------------AEALAMI----------------ESTQQARCL 338

  Fly   245 KKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGW 309
            :.|:.|                                                  .::.||:
Human   339 RDTEQI--------------------------------------------------FREGPVE-- 351

  Fly   310 YKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRR----------MD------------ 352
                       ..:||        .:::|.|....|...:|          :|
Human   352 -----------IGLPC--------SIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPE 397

  Fly   353 -NKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELP 416
             ||:.|   |.:..::..||...|::||||||||.|||.:.|::.:|:|.|:|||::..||:|..
Human   398 LNKERP---SLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECT 459

  Fly   417 MNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAI 481
            |.||::|:|:...|||..|...|||.:.|||||||..|||||||:|...:|..|.|.|||.|:.:
Human   460 MVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIIL 524

  Fly   482 ALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDP 546
            .|.|||.:.|:||||||||||||.:||:|:.|||:.||.:.....|.||||||:|:||||:....
Human   525 GLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQK 589

  Fly   547 YSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNN 611
            |:.:.|||||||||:|.:.||:||.|.||..:|.:|:.....:|:....||.|::.....::|..
Human   590 YNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEK 654

  Fly   612 RLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKL 676
            |||    .|.:|..||.||.::|::.|..|::||.:|.:|...|.||||..|..||..|:..|:.
Human   655 RLG----VRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRA 715

  Fly   677 FMMNLDQNDFIGFSFMNP 694
            .:.::|||.|..||||||
Human   716 LINSMDQNMFRNFSFMNP 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	25/56 (45%)
		C1_1	137..189	CDD:278556	26/51 (51%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	10/129 (8%)
		S_TKc	371..629	CDD:214567	126/257 (49%)
		STKc_PKC	375..692	CDD:270722	150/316 (47%)
PRKCQ	XP_005252553.1	C1_1	194..246	CDD:278556	24/51 (47%)
		C1_1	266..318	CDD:278556	26/56 (46%)
		STKc_nPKC_theta	408..738	CDD:270770	156/330 (47%)
		S_TKc	414..668	CDD:214567	126/257 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910