DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and PKN2

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_006247.1	Gene:	PKN2 / 5586	HGNCID:	9406	Length:	984	Species:	Homo sapiens

Alignment Length:	670	Identity:	199/670 - (29%)
Similarity:	299/670 - (44%)	Gaps:	171/670 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 CENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYI 231
            |::...||....:.|...:.|...||.|...:      ....|.....:.||  :.|:..|:...
Human   338 CQDILENVPGRSKATSVALPGWSPSETRSSFM------SRTSKSKSGSSRNL--LKTDDLSNDVC 394

  Fly   232 AVQMHPDRSGRTKKKTKTI--QKNLNPVFNET----FTFELQPQDRDKRLLIEVW--DWDRTSR- 287
            ||          .|...|:  |.:..|:.|::    ||.||   ||.:.|.|.|:  ||.....
Human   395 AV----------LKLDNTVVGQTSWKPISNQSWDQKFTLEL---DRSRELEISVYWRDWRSLCAV 446

  Fly   288 -----NDFMGS---------------------FSFSLE---ELQKEPVDGWYKFLSQVEGEHY-- 321
                 .||:.:                     |:..:|   :||::.     |..|:.:|:.:
Human   447 KFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQK-----KIFSKQQGKTFLR 506

  Fly   322 ------------------------------------NIPCVD----------AFNDIARLRDEVR 340
                                                .:|.||          :.:.:.:|..::.
Human   507 APQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLE 571

  Fly   341 HDRRP--------------NEKRRMD----------------NKDMPHNMS-------------- 361
            .:..|              :|.|.:|                |..:|.:.|
Human   572 PEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYS 636

  Fly   362 -----------KRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMEL 415
                       :|......||....|:|:|.||||||||.:.|:|::|:|.|:|..|:..|:::.
Human   637 GIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDS 701

  Fly   416 PMNEKKILAL--SGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVE 478
            .|.||:|...  |.|.||||::.:||||.:.:.|||||..|||||.|:.. ..|.|..|:|||..
Human   702 LMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAAC 765

  Fly   479 VAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVS 543
            |.:.|.:|||..|:||||||||:|||.||.||:.||||.|||:.....|.||||||.::|||:::
Human   766 VVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 830

  Fly   544 YDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKK 608
            ...|:.|.|||..|||::|.:.|::||.||||..||.:|.:.:..:|:..|.||:.|:...|.:.
Human   831 ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRN 895

  Fly   609 PNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLT-P 672
            |..||||.....:::..|||||.:||......:::||..|.|:.|:|:|||||.||.|...|| |
Human   896 PERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP 960

  Fly   673 TDKLFMMNLDQNDFIGFSFM 692
            .:...:...:|..|..|.::
Human   961 REPRILSEEEQEMFRDFDYI 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556	5/21 (24%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	33/205 (16%)
		S_TKc	371..629	CDD:214567	121/259 (47%)
		STKc_PKC	375..692	CDD:270722	145/319 (45%)
PKN2	NP_006247.1	HR1_PKN_1	42..107	CDD:212012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..133
		HR1	130..201	CDD:294066
		HR1_PKN2_3	209..282	CDD:212025
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..383		6/37 (16%)
		Necessary to rescue apical junction formation. /evidence=ECO:0000250	382..463		24/95 (25%)
		C2_PKN-like	390..473	CDD:176069	21/95 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..584		2/25 (8%)
		STKc_PKN	657..982	CDD:270741	146/325 (45%)
		S_TKc	662..916	CDD:214567	120/254 (47%)
		Necessary for the catalytic activity	917..977		22/59 (37%)
		Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA	978..984		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840