Protein Alignment inaC and PKN1

DIOPT Version :9

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_998725.1
• Gene: PKN1 / 5585
• HGNCID: 9405
• Length: 948
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 181/532 - (34%)
• Similarity: 269/532 - (50%)
• Gaps: 76/532 - (14%)

  Fly   196 KLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNE 260
            ||..:::.:.:.:::|::....|:...|  |.:|.|      :|..|.:::.|...|.....|
Human   454 KLEDFLDNERHEVQLDMEPQGCLVAEVT--FRNPVI------ERIPRLRRQKKIFSKQQGKAF-- 508

  Fly   261 TFTFELQPQDRDKRLLIEVWDWDRTSRN-----DFMGSFSFSLEELQKEPVDGWYKFLSQVEGEH 320
                     .|.:::.|:|..|.|..|.     ...|:||.......:....|      .:..|.
Human   509 ---------QRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTTG------DISVEK 558

  Fly   321 YNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMS------------------------ 361
            .|:. .|:             |..|.:..| |....|.::|
Human   559 LNLG-TDS-------------DSSPQKSSR-DPPSSPSSLSSPIQESTAPELPSETQETPGPALC 608

  Fly   362 ---KRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKIL 423
               ::..:...||.|:.|:|:|.||||||:|.|.:.||:|:|.|:|..|:..|::|..|.||:||
Human   609 SPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRIL 673

  Fly   424 A--LSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFL 486
            |  .|...||||::..||||.:.:.|||||..|||||.|:.. ..|.|..||||:..|.:.|.||
Human   674 AAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFL 737

  Fly   487 HERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAA 551
            ||..|:||||||||:|||.||:||:.||||.|||:.....|.||||||.::|||:::...|:.|.
Human   738 HEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAV 802

  Fly   552 DWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAG 616
            |||..||||:|.:.|::||.||||..||.:|.:.:..:|:..|.||:.|:...|.:.|..|||:.
Human   803 DWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSS 867

  Fly   617 RYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLT-PTDKLFMMN 680
            ....:::...||||.:.|:...|..:.||..|.:..|.|:||||:.||.|...|: |.|...:..
Human   868 ERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTA 932

  Fly   681 LDQNDFIGFSFM 692
            .:|..|:.|.|:
Human   933 AEQAAFLDFDFV 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992	25/132 (19%)
		S_TKc	371..629	CDD:214567	124/259 (48%)
		STKc_PKC	375..692	CDD:270722	145/319 (45%)
PKN1	NP_998725.1	HR1_PKN_1	<52..104	CDD:212012
		HR1_PKN1_2	127..202	CDD:212020
		HR1_PKN1_3	211..284	CDD:212026
		C2_PKN-like	395..482	CDD:176069	5/29 (17%)
		STKc_PKN	621..945	CDD:270741	148/325 (46%)
		S_TKc	621..880	CDD:214567	124/259 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840