DRSC/TRiP Functional Genomics Resources

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Protein Alignment inaC and PRKCI

DIOPT Version :9

Sequence 1:NP_476863.1 Gene:inaC / 36897 FlyBaseID:FBgn0004784 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_002731.4 Gene:PRKCI / 5584 HGNCID:9404 Length:596 Species:Homo sapiens


Alignment Length:689 Identity:219/689 - (31%)
Similarity:304/689 - (44%) Gaps:218/689 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 PSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFK 80
            |.||. .||...|               ||.      |:..|:||.:.:.|...|||.|..:.|.
Human   107 PCVPE-RPGMPCP---------------GED------KSIYRRGARRWRKLYCANGHTFQAKRFN 149

  Fly    81 NPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYT 145
            ...:|..|.|.|||.|:||::|..|:..:|:||.|.|..                          
Human   150 RRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTI-------------------------- 188

  Fly   146 TPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKV 210
                  |||.                   |...||.|                            
Human   189 ------ECGR-------------------HSLPQEPV---------------------------- 200

  Fly   211 DIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRL 275
                    :|||.:         .||.|.:       :|:.. .||..:|:              
Human   201 --------MPMDQS---------SMHSDHA-------QTVIP-YNPSSHES-------------- 226

  Fly   276 LIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVR 340
                                                 |.|| ||                     
Human   227 -------------------------------------LDQV-GE--------------------- 232

  Fly   341 HDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKD 405
                  ||..|:.::.....|.   :...||:.::|||:||:.||||...:.||.:||:||::|:
Human   233 ------EKEAMNTRESGKASSS---LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKE 288

  Fly   406 VIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKES 470
            ::...:|::....||.:...:...||||.:||||||..|||||:||..|||||:|||:..:..|.
Human   289 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE 353

  Fly   471 VAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPN 535
            .|.||:.|:::||.:||||.||||||||||:|||.|||:||.|:|:.|||:....||.|||||||
Human   354 HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPN 418

  Fly   536 YMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPF------EGDDETT---VFRNIKDKKAVFPK 591
            |:||||:..:.|..:.|||:.|||:||.|||::||      :..|:.|   :|:.|.:|:...|:
Human   419 YIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 483

  Fly   592 HFSVEAMDIITSFLTKKPNNRLGA-GRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKD 655
            ..||:|..::.|||.|.|..|||. .:....:|..||||||||||..|..::.||.||.|.....
Human   484 SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFG 548

  Fly   656 ISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNP 694
            :.|||..||.|...|||.|...:..:||::|.||.::||
Human   549 LDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
inaCNP_476863.1 C1_1 72..124 CDD:278556 19/51 (37%)
C1_1 137..189 CDD:278556 7/51 (14%)
C2_PKC_alpha_gamma 194..324 CDD:175992 15/129 (12%)
S_TKc 371..629 CDD:214567 127/267 (48%)
STKc_PKC 375..692 CDD:270722 155/326 (48%)
PRKCINP_002731.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Regulatory domain 2..253 60/353 (17%)
Required for interaction with RAB2 2..28