Protein Alignment inaC and PRKCH

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_047287541.1
• Gene: PRKCH / 5583
• HGNCID: 9403
• Length: 782
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 253/709 - (35%)
• Similarity: 358/709 - (50%)
• Gaps: 172/709 - (24%)

  Fly    28 PAAGAGKGPGN-------------------LLEITGEANIVNYMKNRL-------RKGAMKRKGL 66
            |...:|:|||.                   ::.:||........::|:       |:.||:|: :
Human   202 PNGKSGRGPGRSPFPPSLWVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRR-V 265

  Fly    67 EMVNGHRFGVRFFKNPTYCGHCKDFIWG-FGKQGFQCEECRFNIHQKCCKFVVFKCPGKD--TDF 128
            ..:|||:|...:.:.||||.||::|||| |||||:||:.|...:|::|...:|..|..::  ...
Human   266 HQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKV 330

  Fly   129 DADCAK------VKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCG 187
            |:..|:      :.|.:....|..|||||.||.||.|:..||::|:.|.:|||..||..|.|.||
Human   331 DSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCG 395

  Fly   188 ADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQK 252
            .:..|: .|.|..:.|:..|    |...:.|:...|
Human   396 VNAVEL-AKTLAGMGLQPGN----ISPTSKLVSRST----------------------------- 426

  Fly   253 NLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVE 317
                         |:.|.::                                         |..|
Human   427 -------------LRRQGKE-----------------------------------------SSKE 437

  Fly   318 GEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRM--DNKDMPHNMSKRDMIRAADFNFVKVIGKG 380
            |....:                      |...|:  ||                 |.|::|:|||
Human   438 GNGIGV----------------------NSSNRLGIDN-----------------FEFIRVLGKG 463

  Fly   381 SFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRL 445
            |||||:||..:.|.:|||||||:||||:|.||:|..|.||:||:|:...|||..:..||||.|||
Human   464 SFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRL 528

  Fly   446 FFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVK 510
            |||||:..|||||:|:|:..||.|:.|.|||.|:..||.|||::.||||||||||:|||.|||.|
Human   529 FFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCK 593

  Fly   511 LVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDE 575
            |.|||:.|||:....||.||||||:|:||||:....|..|.|||:.||||:|.:.|.||||.::|
Human   594 LADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENE 658

  Fly   576 TTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGA----GRYARQEITTHPFFRNVDWDK 636
            ..:|..|.:.:.|:|.....:|..|:.||:||.|..|||:    |.:|   |..||||:.:||.:
Human   659 DDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHA---ILRHPFFKEIDWAQ 720

  Fly   637 AEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPE 695
            ....::|||.:|.||.|:|:||||..|.||:..|||.|:..:..::|::|..||:::||
Human   721 LNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342	25/52 (48%)
		C1	137..190	CDD:412127	25/52 (48%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	12/129 (9%)
		STKc_PKC	375..692	CDD:270722	167/320 (52%)
PRKCH	XP_047287541.1	C2_PKC_epsilon	8..122	CDD:175981
		C1_nPKC_epsilon-like_rpt1	265..325	CDD:410385	26/59 (44%)
		C1_nPKC_epsilon-like_rpt2	343..397	CDD:410388	25/53 (47%)
		STKc_nPKC_eta	458..780	CDD:270742	169/325 (52%)