DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and PRKCG

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001303258.1	Gene:	PRKCG / 5582	HGNCID:	9402	Length:	710	Species:	Homo sapiens

Alignment Length:	687	Identity:	344/687 - (50%)
Similarity:	456/687 - (66%)	Gaps:	28/687 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFG 96
            ||.|||......|...:.      .||||:::|.:..|..|:|..||||.||:|.||.|||||.|
Human     2 AGLGPGVGDSEGGPRPLF------CRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG 60

  Fly    97 KQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLHGVA 161
            |||.||:.|.|.:|::|.:||.|:|||.......|..:.||.:...:|::|||||.||.||:|:.
Human    61 KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLV 125

  Fly   162 HQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVEL-KGNNLKVDIKEAANLIPMDTNG 225
            |||:||..|.:|||..|..:||.:||.|.:|.||:|.|.:.. ..:.:.|.:.||.||||||.||
Human   126 HQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNG 190

  Fly   226 FSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDF 290
            .||||:.:::.||....||:||:|::..||||:||||.|.|:|.|.::||.:|||||||||||||
Human   191 LSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDF 255

  Fly   291 MGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFN-DIARLRDEVRHDRRPNEKRRMDNK 354
            ||:.||.:.||.|.|||||||.|:|.|||:||:|..||.| .:.:..:...:.....|:.||...
Human   256 MGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPS 320

  Fly   355 DMP---HNMSKRD-----------MIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKD 405
            ..|   .:.|..|           .:..:||:|:.|:||||||||:||||||:|||||:|:|:||
Human   321 SSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKD 385

  Fly   406 VIIQTDDMELPMNEKKILAL-----SGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYG 465
            ||:|.||::..:.||::|||     .|||.||..:||.|||.|||:|||||..|||||||:||.|
Human   386 VIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG 450

  Fly   466 RFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTF 530
            :|||..|.|||.|:||.|||||.:.||||||||||::||.|||:|:.|||:.||.|....|||||
Human   451 KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTF 515

  Fly   531 CGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSV 595
            ||||:|:||||::|.||..:.|||||||||:|.:|||.||:|:||..:|:.|.::...:||..|.
Human   516 CGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSR 580

  Fly   596 EAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFD 660
            ||:.|...||||.|..|||:|......|..|.|||.:||::.|..|:.||.:|....|.. .|||
Human   581 EAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENFD 644

  Fly   661 DAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFI 697
            ..||:....|||.|:|.:.::||.||.||:::||:|:
Human   645 KFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFV 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	31/51 (61%)
		C1_1	137..189	CDD:278556	26/51 (51%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	74/130 (57%)
		S_TKc	371..629	CDD:214567	155/262 (59%)
		STKc_PKC	375..692	CDD:270722	180/321 (56%)
PRKCG	NP_001303258.1	C1_1	36..88	CDD:278556	31/51 (61%)
		C1_1	101..153	CDD:278556	26/51 (51%)
		C2_PKC_alpha_gamma	158..289	CDD:175992	74/130 (57%)
		S_TKc	351..614	CDD:214567	155/262 (59%)
		STKc_cPKC	354..677	CDD:270739	180/323 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103255
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.710