Protein Alignment inaC and PRKCD

DIOPT Version :9

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001341605.1
• Gene: PRKCD / 5580
• HGNCID: 9399
• Length: 695
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 234/654 - (35%)
• Similarity: 323/654 - (49%)
• Gaps: 141/654 - (21%)

  Fly    57 RKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKC 121
            |:||:|:..:..:..|.|...||..||:|..||||:||..|||::|.:|...||:||...::.:|
Human   163 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 227

  Fly   122 PG-----KDTDFDADCAKV--KHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQ 179
            .|     :||.|..:...:  .|.:....|.:|||||.||.||.|:..||:|||:|.:||||.|:
Human   228 TGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCR 292

  Fly   180 ETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTK 244
            |.|..:||     :..|||              .||.|.:.
Human   293 EKVANLCG-----INQKLL--------------AEALNQVT------------------------ 314

  Fly   245 KKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGW 309
                                                  .|.||..         :....|||..:
Human   315 --------------------------------------QRASRRS---------DSASSEPVGIY 332

  Fly   310 YKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMI-------R 367
            ..|                                 .:|..:..:||..|......|       .
Human   333 QGF---------------------------------EKKTGVAGEDMQDNSGTYGKIWEGSSKCN 364

  Fly   368 AADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFL 432
            ..:|.|.||:||||||||||.|.:|..|.:|:|.|:|||::..||:|..|.||::|.|:...|||
Human   365 INNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 429

  Fly   433 VSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLK 497
            ..:...|||.|.||||||:..|||||||:|..|||:...|.|||.|:...|.|||.:.|||||||
Human   430 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLK 494

  Fly   498 LDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFE 562
            |||:|||.:||:|:.|||:.||.:.......||||||:|:||||:....|:.:.|||||||||:|
Human   495 LDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 559

  Fly   563 FMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHP 627
            .:.||:||.||||..:|.:|:.....:|:..:.|:.||:.....::|..|||    ....|..||
Human   560 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLG----VTGNIKIHP 620

  Fly   628 FFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFM 692
            ||:.::|...|...:|||.:|.:|..:|.||||..|..||..|:.:||..:.::||:.|.||||:
Human   621 FFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFV 685

  Fly   693 NPEF 696
            ||:|
Human   686 NPKF 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	24/56 (43%)
		C1_1	137..189	CDD:278556	27/51 (53%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	13/129 (10%)
		S_TKc	371..629	CDD:214567	128/257 (50%)
		STKc_PKC	375..692	CDD:270722	152/316 (48%)
PRKCD	NP_001341605.1	C1_1	178..227	CDD:278556	22/48 (46%)
		C1_1	250..302	CDD:278556	27/56 (48%)
		STKc_nPKC_delta	372..687	CDD:173710	153/318 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910