Protein Alignment inaC and PRKACA

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001291278.1
• Gene: PRKACA / 5566
• HGNCID: 9380
• Length: 427
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 119/351 - (33%)
• Similarity: 184/351 - (52%)
• Gaps: 33/351 - (9%)

  Fly   343 RRPNEKRRMDNKDMPHNMSKRDMIRAAD------------------FNFVKVIGKGSFGKVLLAE 389
            |||          .|.|:.|..:.:|.:                  |..:|.:|.||||:|:|.:
Human    84 RRP----------WPWNVVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVK 138

  Fly   390 RRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKG 454
            .:.|...||:|:|.|..:::...:|..:|||:||. :...||||.:...|:....|:.||||..|
Human   139 HKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQ-AVNFPFLVKLEFSFKDNSNLYMVMEYVPG 202

  Fly   455 GDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKE 519
            |::..|:::.|||.|..|.|||.::.:...:||..|:||||||.:|:|:|.:|::::.|||.:|.
Human   203 GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 267

  Fly   520 GVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKD 584
               .:..|.|.||||.|:||||:....|:.|.|||:.|||::|..||..||..|....::..|..
Human   268 ---VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 329

  Fly   585 KKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPM 649
            .|..||.|||.:..|::.:.|......|.|..:....:|..|.:|...||......::|.|..|.
Human   330 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 394

  Fly   650 IKHRKDISNFDDAFTKEKTDLTPTDK 675
            .|...|.||||| :.:|:..::..:|
Human   395 FKGPGDTSNFDD-YEEEEIRVSINEK 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342
		C1	137..190	CDD:412127
		C2_PKC_alpha_gamma	194..324	CDD:175992
		STKc_PKC	375..692	CDD:270722	111/301 (37%)
PRKACA	NP_001291278.1	STKc_PKA	118..407	CDD:271111	110/293 (38%)