DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and prkcaa

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_021332537.1	Gene:	prkcaa / 497384	ZFINID:	ZDB-GENE-050208-100	Length:	679	Species:	Danio rerio

Alignment Length:	657	Identity:	344/657 - (52%)
Similarity:	464/657 - (70%)	Gaps:	14/657 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NRL-RKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFV 117
            ||. ||||:::|.:..|..|:|..||||.||:|.||.|||||||||||||:.|.|.:|::|.:.|
Zfish    16 NRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHELV 80

  Fly   118 VFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETV 182
            .|.|||.|...|.|..:.||.:...||.:|||||.||.||:|:.|||:||::|::|||..|...|
Zfish    81 TFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDSCDMNVHKQCVMNV 145

  Fly   183 PPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKT 247
            |.:||.|.:|.||:|.:.:|:.|:.:.|.:.|..||||||.||.||||:.:::.||....||:||
Zfish   146 PSLCGTDHTERRGRLYMKIEVIGDKMHVTVGEGKNLIPMDPNGLSDPYVKLKLIPDPKNETKQKT 210

  Fly   248 KTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKF 312
            |||:.:|||.:||||||:|:|.|:|:||.:||||||||:|||||||.||.:.||.|.||.||||.
Zfish   211 KTIRSSLNPTWNETFTFKLKPADKDRRLAVEVWDWDRTTRNDFMGSMSFGVSELMKSPVCGWYKM 275

  Fly   313 LSQVEGEHYNIPCVDAFNDIARLR----DEVRHDRR------PNEKR--RMDNKDMPHNMSKRDM 365
            |:|.|||:||:|..|..:....||    ||...|..      |.:|.  .:|:.......|..|.
Zfish   276 LNQEEGEYYNVPIPDEDDPDTELRQKFEDETLEDLEQIAKLGPPKKNITALDDSGSSITSSNVDN 340

  Fly   366 IRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPP 430
            :|.:||||:.|:||||||||:|||.:.:|||:|:|:|:|||:||.||:|..|.||::||...:||
Zfish   341 VRLSDFNFLAVLGKGSFGKVMLAEMKSSDELFAIKILKKDVVIQDDDVECTMVEKRVLAQQDKPP 405

  Fly   431 FLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRD 495
            ||..:||||||:|||:|||||..|||||||:||.|:|||..|:|||.|:|:.|||||::.|||||
Zfish   406 FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEIAVGLFFLHKKGIIYRD 470

  Fly   496 LKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLL 560
            |||||::||.|||:|:.|||:.||.:.|..|||||||||:|:||||::|.||..:.|||::||||
Zfish   471 LKLDNVMLDAEGHIKIADFGMCKENIVEGVTTRTFCGTPDYIAPEIIAYQPYGRSVDWWAYGVLL 535

  Fly   561 FEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITT 625
            :|.:|||.||:|:||..:|::|.:....:.|..|.||:.|....:||.|:.|||.|:...::|..
Zfish   536 YEMLAGQPPFDGEDEDELFQSIMEHNVSYSKTLSKEAVSICKGLMTKHPSKRLGCGQEGERDIRE 600

  Fly   626 HPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFS 690
            |.|||.:|||:....|::||.||.: ..|...|||..||:.:..|||.|:|.:.|:||.||.||:
Zfish   601 HAFFRRIDWDRLANREVQPPFKPKV-CGKGAENFDKFFTRTQPQLTPPDELVIANIDQADFDGFT 664

  Fly   691 FMNPEFI 697
            |:||:|:
Zfish   665 FVNPQFV 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	32/51 (63%)
		C1_1	137..189	CDD:278556	27/51 (53%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	76/129 (59%)
		S_TKc	371..629	CDD:214567	147/257 (57%)
		STKc_PKC	375..692	CDD:270722	173/316 (55%)
prkcaa	XP_021332537.1	C1_1	35..87	CDD:278556	32/51 (63%)
		C1_1	100..150	CDD:278556	25/49 (51%)
		C2_PKC_alpha_gamma	157..287	CDD:175992	76/129 (59%)
		STKc_cPKC_alpha	335..675	CDD:270766	184/338 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583302
Domainoid	1	1.000	43	1.000	Domainoid score	I12367
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103255
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850