DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and prkcbb

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_957272.1	Gene:	prkcbb / 393953	ZFINID:	ZDB-GENE-040426-1178	Length:	670	Species:	Danio rerio

Alignment Length:	656	Identity:	347/656 - (52%)
Similarity:	465/656 - (70%)	Gaps:	19/656 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 MKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKF 116
            |:...|:||:::|.:..|..|:|..||||.||:|.||.|||||||||||||:.|.|.:|::|.:|
Zfish    16 MRGFARQGALRQKNVHEVKNHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 80

  Fly   117 VVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQET 181
            |.|.|||.|....:|..:.||.:...||::|||||.||.||:|:.|||::|::|.:|:|..|...
Zfish    81 VTFSCPGADKGPASDDPRSKHKFKVHTYSSPTFCDHCGSLLYGLIHQGMRCDHCMMNIHKRCVAN 145

  Fly   182 VPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKK 246
            ||.:||.|.:|.||::.:..|:|.|.|.|.||||.||:|||.||.||||:.:::.||....:|:|
Zfish   146 VPSLCGTDHTERRGRIQITAEIKNNVLTVSIKEAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQK 210

  Fly   247 TKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYK 311
            ||||:..|||.:||||||.|:..|:|:||.:|:||||.|||||||||.||.:.||||:.||||:|
Zfish   211 TKTIKCCLNPTWNETFTFNLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKQGVDGWFK 275

  Fly   312 FLSQVEGEHYNIPCV---DAFNDIARLRDEVRHDRRP--------NEKRRMDNKDMPHNMSKRDM 365
            .|||.|||::|:|..   :..|:..|.:.| |....|        |...:.|:.      ..||.
Zfish   276 LLSQEEGEYFNVPVPPEGEEGNEELRQKFE-RAKIGPSKTDGSSSNAISKFDSN------GNRDR 333

  Fly   366 IRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPP 430
            ::.:||||:.|:||||||||:||||:|.|||:|:|:|:|||:||.||:|..|.||::|||||:||
Zfish   334 MKLSDFNFLMVLGKGSFGKVMLAERKGADELFAIKILKKDVVIQDDDVECTMVEKRVLALSGKPP 398

  Fly   431 FLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRD 495
            ||..:||||||||||:|||||..|||||||:||.|:|||..|:|||.|:||.|||||.:.:||||
Zfish   399 FLTQLHSCFQTMDRLYFVMEYINGGDLMYHIQQVGKFKEPHAVFYAAEIAIGLFFLHSKGVIYRD 463

  Fly   496 LKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLL 560
            |||||::||.|||:|:.|||:.||.:.:..||:||||||:|:||||::|.||..:.|||:|||||
Zfish   464 LKLDNVMLDAEGHIKIADFGMCKENMLDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLL 528

  Fly   561 FEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITT 625
            :|.:|||.||:|:||..:|::|.:....:||..|.||:.|....:||.|..|||.|....::|..
Zfish   529 YEMLAGQPPFDGEDEDELFQSIMEHHVSYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIRE 593

  Fly   626 HPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFS 690
            |.|||.:||:|.|..|::||.||....| |..|||..||:....|||.|:..:|||||::|.|||
Zfish   594 HGFFRYMDWEKLEHREVQPPFKPKACGR-DAENFDRFFTRHPPVLTPPDQEVIMNLDQDEFEGFS 657

  Fly   691 FMNPEF 696
            |:||||
Zfish   658 FINPEF 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	33/51 (65%)
		C1_1	137..189	CDD:278556	25/51 (49%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	76/129 (59%)
		S_TKc	371..629	CDD:214567	153/257 (60%)
		STKc_PKC	375..692	CDD:270722	182/316 (58%)
prkcbb	NP_957272.1	C1_1	36..88	CDD:278556	33/51 (65%)
		C1_1	101..151	CDD:278556	23/49 (47%)
		C2_PKC_alpha_gamma	158..288	CDD:175992	76/129 (59%)
		STKc_cPKC_beta	338..660	CDD:270767	187/322 (58%)
		S_TKc	339..597	CDD:214567	153/257 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583305
Domainoid	1	1.000	43	1.000	Domainoid score	I12367
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103255
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.710