DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and akt2

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_937789.1	Gene:	akt2 / 378972	ZFINID:	ZDB-GENE-031007-5	Length:	479	Species:	Danio rerio

Alignment Length:	472	Identity:	158/472 - (33%)
Similarity:	236/472 - (50%)	Gaps:	61/472 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 KKKTKTIQKNLNPVFNETFTFELQ----PQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKE 304
            |:|.:|...| .|..|.....|.|    .:.|....:|....|.......|....:...||
Zfish    39 KEKPETSDAN-QPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSNSEREE---- 98

  Fly   305 PVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNM--------- 360
                |.:.:..|.            |.:               |.|.:::.|..|.
Zfish    99 ----WIRAIQAVA------------NGL---------------KSREEDEPMDINFGSPGDNSLE 132

  Fly   361 -------SKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMN 418
                   ..|..:..:||:::|::|||:||||:|...:.|...||:|:|||:|||..|::...:.
Zfish   133 GMEAAITKSRTKVTMSDFDYLKLLGKGTFGKVILVREKATGMYYAMKILRKEVIIAKDEVAHTIT 197

  Fly   419 EKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIAL 483
            |.::|. :.|.|||.::...|||.|||.|||||..||:|.:|:.:...|.|..|.||..|:..||
Zfish   198 ESRVLQ-NTRHPFLTTLKYAFQTRDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSAL 261

  Fly   484 FFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYS 548
            .:||.:|::||||||:|::||.:||:|:.||||.|||:|...|.:||||||.|:|||::..:.|.
Zfish   262 EYLHSKDVVYRDLKLENLMLDKDGHIKITDFGLCKEGITNEATMKTFCGTPEYLAPEVLEDNDYG 326

  Fly   549 IAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRL 613
            .|.|||..||:::|.|.|:.||...|...:|..|..::..||::.|.||..::...|.|.|..||
Zfish   327 RAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRNLSPEAKALLAGLLKKDPKQRL 391

  Fly   614 GAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFM 678
            |.|....:|:.||.||.|::|......::.||.||.:....|...|||.||.:...:||.|:...
Zfish   392 GGGPEDAKEVMTHKFFNNMNWQDVLQKKLVPPFKPQVTSETDTRYFDDEFTAQTITVTPPDQYDS 456

  Fly   679 MNLDQND----FIGFSF 691
            ::.:..|    |..||:
Zfish   457 LDAEDPDTRTHFSQFSY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992	16/83 (19%)
		S_TKc	371..629	CDD:214567	114/257 (44%)
		STKc_PKC	375..692	CDD:270722	134/321 (42%)
akt2	NP_937789.1	PH_PKB	4..111	CDD:269947	17/107 (16%)
		PH	6..106	CDD:278594	15/75 (20%)
		S_TKc	150..407	CDD:214567	114/257 (44%)
		STKc_PKB_beta	154..476	CDD:173686	134/321 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920