DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and pkn3

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_003198687.2	Gene:	pkn3 / 323182	ZFINID:	ZDB-GENE-030131-1902	Length:	940	Species:	Danio rerio

Alignment Length:	736	Identity:	218/736 - (29%)
Similarity:	331/736 - (44%)	Gaps:	128/736 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LPPSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRF 78
            ||...|..|  |.......|..||           :...:.|||..:.....|
Zfish   271 LPQDHPKRA--AIKEELTVGSSPG-----------IGLQRERLRSSSSASSSL------------ 310

  Fly    79 FKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTT 143
            ||..:..|..:..:.|       |::...::..:|....:...||..:  |:...:::.| :||.
Zfish   311 FKPASLTGRLEVRLMG-------CQDLLESVPGRCRVSNMSSAPGSPS--DSKSLRMRTG-LSTR 365

  Fly   144 YTT--PTFCDECGLLLHGVAHQGVKCENCNLNVHH-------ACQETVP---------------- 183
            .|.  .|..||....:..|    :|.:|..:...|       |..::..
Zfish   366 STNGKTTKTDELSSEISAV----LKVDNKIVGRTHWRPLSKDAWNQSFSIELERSRELEIAVYWR 426

  Fly   184 ---PMCGAD-------ISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHP- 237
               .:|...       :...|..:.||:|.:| .|..:::            |.:|  .::.||
Zfish   427 DWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQG-TLFTEVR------------FINP--VIERHPK 476

  Fly   238 -DRSGR--TKKKTKTI----QKNLN------------PVFNETFTFELQPQDRDKRLLIEVWDWD 283
             .|..|  .|:|.|..    |.|:|            |..|.|.|....|....:.|........
Zfish   477 LQRQKRIFPKEKGKNFLRAAQMNMNFATWGRLMMSVLPPCNSTITALSPPLPGSEPLSPPSVSTP 541

  Fly   284 RTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEK 348
            .::.:..:...:||.|...|.|    ...|:|       .|..|........|.....|||..:.
Zfish   542 PSTGDSAVVKLNFSEERPTKPP----RLHLAQ-------NPSADESLSGTPARVNSTEDRRVLQA 595

  Fly   349 RRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDM 413
            |.. ::..|   .:::.::..|||.:.|:|:|.||||||||.:.|.:|||:|.|:|..::..|::
Zfish   596 RPA-SQPTP---QRKEGMQMEDFNCISVLGRGHFGKVLLAEFKRTGKLYAIKALKKGDVVTRDEV 656

  Fly   414 ELPMNEKKILAL--SGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYA 476
            :..|.||:|...  :.|.||||:::.||||.|.:.|||||..|||||.|:.. ..|.|..|.||:
Zfish   657 DSLMCEKRIFETINASRHPFLVNLYGCFQTPDHVCFVMEYSPGGDLMTHIHN-NIFSERQARFYS 720

  Fly   477 VEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEI 541
            ..|.:.|.|||:..|:||||||||:|:|.:|.|::.||||.|||:.....|.||||||.::|||:
Zfish   721 ACVLLGLEFLHQNRIVYRDLKLDNLLMDSDGFVRIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 785

  Fly   542 VSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLT 606
            ::...|:.|.|||..|||::|.:.|::||.||||..||.:|.:.:..:|:..|.|::.:|...|.
Zfish   786 LTDSNYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFMSPESVSVIQKLLQ 850

  Fly   607 KKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLT 671
            |....|||||.....|:..|.||:.:||:...|..::||..|.||...|:||||:.||:.|..||
Zfish   851 KNSEKRLGAGEQDANEVKKHRFFQGIDWEALLAKRVKPPFLPSIKTAADVSNFDEEFTRLKPVLT 915

  Fly   672 PTDKLFMMNLDQNDFIG-FSF 691
            |....|.::.:|.:|.. |.|
Zfish   916 PPQTPFFLSAEQQEFFADFDF 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	7/51 (14%)
		C1_1	137..189	CDD:278556	13/79 (16%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	31/149 (21%)
		S_TKc	371..629	CDD:214567	118/259 (46%)
		STKc_PKC	375..692	CDD:270722	142/320 (44%)
pkn3	XP_003198687.2	HR1_PKN_1	25..90	CDD:212012
		HR1	111..183	CDD:320753
		HR1_PKN3_3	199..271	CDD:212027	218/736 (30%)
		C2_PKN-like	379..462	CDD:176069	12/87 (14%)
		STKc_PKN	614..938	CDD:270741	144/324 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930