DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and PKN3

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_006717143.1	Gene:	PKN3 / 29941	HGNCID:	17999	Length:	896	Species:	Homo sapiens

Alignment Length:	366	Identity:	146/366 - (39%)
Similarity:	202/366 - (55%)	Gaps:	9/366 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 DEVRHDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKV 401
            :|....:||:.:.|......|.....|...|..||..:.|:|:|.||||||.:.:||.:.||:|.
Human   532 EETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKA 596

  Fly   402 LRKDVIIQTDDMELPMNEKKILALSG--RPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQY 464
            |:|..::..|::|....||:||...|  ..|||:|:.:||||.....||.|:..|||||..:.:
Human   597 LKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE- 660

  Fly   465 GRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRT 529
            ..|.|..|.||...|.:.|.||||:.||||||||||:|||.:|.:|:.||||.|||:.....|.|
Human   661 DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTST 725

  Fly   530 FCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFS 594
            |||||.::|||:::.:.|:.|.|||..||||:|.:.|:.||.||.|..||..|.:..|.:|...|
Human   726 FCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLS 790

  Fly   595 VEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNF 659
            |:.::.|...|.|.|..|||||....:||...||||..:|....|..::||..|.:....|:..|
Human   791 VQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYF 855

  Fly   660 DDAFTKEKTDLTPTDKLFMMNLDQN------DFIGFSFMNP 694
            :..||.....|||.....::...|.      ||:...|:.|
Human   856 EGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992
		S_TKc	371..629	CDD:214567	118/259 (46%)
		STKc_PKC	375..692	CDD:270722	135/324 (42%)
PKN3	XP_006717143.1	HR1_PKN_1	20..85	CDD:212012
		HR1_PKN3_2	104..177	CDD:212022
		HR1	177..237	CDD:294066
		C2	335..417	CDD:301316
		STKc_PKN	566..891	CDD:270741	136/325 (42%)
		S_TKc	566..825	CDD:214567	118/259 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149231
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840