DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment inaC and Sgk1

DIOPT Version :9

Sequence 1:NP_476863.1 Gene:inaC / 36897 FlyBaseID:FBgn0004784 Length:700 Species:Drosophila melanogaster
Sequence 2:XP_006227785.1 Gene:Sgk1 / 29517 RGDID:3668 Length:525 Species:Rattus norvegicus


Alignment Length:477 Identity:160/477 - (33%)
Similarity:239/477 - (50%) Gaps:60/477 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 TIQKN-LNPVFNETFTFELQPQDRDK------RLLIE-----VWDWD--------RTSRNDFMGS 293
            |.|:. |:|  .|:.::|:||....|      .:|.:     .|..|        |...|||:..
  Rat    73 TFQRGMLSP--EESRSWEIQPGGEVKEPCNHANILTKPDPRTFWTSDDPAFMKQRRMGLNDFIQK 135

  Fly   294 FSFSLEELQKEPVDGWYKFLSQVEGEHYNI-----PCVDAFNDIARLRDEVRHDRRPNEKRRMDN 353
            .:.:....:...|..:.|.....|.|..|.     |                   .|:::..:..
  Rat   136 LANNSYACKHPEVQSYLKISQPQEPELMNANPSPPP-------------------SPSQQINLGP 181

  Fly   354 KDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMN 418
            ...||       .:.:||:|:||||||||||||||..:..:..||||||:|..|::..:.:..|:
  Rat   182 SSNPH-------AKPSDFHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMS 239

  Fly   419 EKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIAL 483
            |:.:|..:.:.||||.:|..|||.|:|:||::|..||:|.||:|:...|.|..|.|||.|:|.||
  Rat   240 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASAL 304

  Fly   484 FFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYS 548
            .:||..:|:|||||.:|||||.:||:.|.||||.||.:....||.||||||.|:|||::...||.
  Rat   305 GYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYD 369

  Fly   549 IAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRL 613
            ...|||..|.:|:|.:.|..||...:...::.||.:|......:.:..|..::...|.|....||
  Rat   370 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 434

  Fly   614 GAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKE----KTDLTPTD 674
            || :....||.:|.||..::||.....::.||..|.:....|:.:||..||:|    ....:|..
  Rat   435 GA-KDDFMEIKSHIFFSLINWDDLINKKITPPFNPNVSGPSDLRHFDPEFTEEPVPSSIGRSPDS 498

  Fly   675 KLFMMNLDQ--NDFIGFSFMNP 694
            .|...::.:  ..|:|||:..|
  Rat   499 ILVTASVKEAAEAFLGFSYAPP 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
inaCNP_476863.1 C1_1 72..124 CDD:278556
C1_1 137..189 CDD:278556
C2_PKC_alpha_gamma 194..324 CDD:175992 21/99 (21%)
S_TKc 371..629 CDD:214567 114/257 (44%)
STKc_PKC 375..692 CDD:270722 131/322 (41%)
Sgk1XP_006227785.1 S_TKc 192..449 CDD:214567 114/257 (44%)
STKc_SGK 196..518 CDD:270727 131/322 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D614710at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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