DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and Pkn1

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_006255307.1	Gene:	Pkn1 / 29355	RGDID:	69308	Length:	951	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	181/533 - (33%)
Similarity:	270/533 - (50%)	Gaps:	77/533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 KLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNE 260
            ||..:::.:.:.:::|::....|:...|  |.:|.|      :|..|.:::.|...|.....|
  Rat   456 KLEDFLDNERHEVQLDMEPQGCLVAEVT--FRNPII------ERIPRLQRQKKIFSKQQGQTF-- 510

  Fly   261 TFTFELQPQDRDKRLLIEVWDWDRTSRNDF-----MGSFS--------------FSLEEL----- 301
                     .|.:::.|:|..|.|..|...     .||||              .|:|:|
  Rat   511 ---------QRARQMNIDVATWVRLLRRLIPNAVATGSFSPNASPGSEIRSTGDISMEKLNLGAD 566

  Fly   302 -----QKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPH--- 358
                 ||.|.               .:|....      ......|:...:.:...:.::.|.
  Rat   567 SDSSSQKSPA---------------GLPSTSC------SLSSPTHESTTSPELPSETQETPGPGL 610

  Fly   359 -NMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKI 422
             :..::..:...||.|:.|:|:|.||||||:|...:.||:|:|.|:|..|:..|::|..|.||:|
  Rat   611 CSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFHSSGELFAIKALKKGDIVARDEVESLMCEKRI 675

  Fly   423 LALSGRP--PFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFF 485
            ||...|.  ||||::..||||.:.:.|||||..|||||.|:.. ..|.|..|:||:..|.:.|.|
  Rat   676 LATVTRAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAVFYSACVVLGLQF 739

  Fly   486 LHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIA 550
            |||..|:||||||||:|||.||:||:.||||.|||:.....|.||||||.::|||:::...|:.|
  Rat   740 LHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRA 804

  Fly   551 ADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGA 615
            .|||..||||:|.:.|::||.||||..||.:|.:.:..:|:..|.||:.|:...|.:.|..|||:
  Rat   805 VDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGS 869

  Fly   616 GRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLT-PTDKLFMM 679
            .....:::...||||.:|||...|..:.||..|.:..|.|:||||:.||.|...|: |.|...:.
  Rat   870 TERDAEDVKKQPFFRTLDWDALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLT 934

  Fly   680 NLDQNDFIGFSFM 692
            ..:|..|..|.|:
  Rat   935 AAEQAAFRDFDFV 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992	29/156 (19%)
		S_TKc	371..629	CDD:214567	122/259 (47%)
		STKc_PKC	375..692	CDD:270722	145/319 (45%)
Pkn1	XP_006255307.1	HR1_PKN_1	37..103	CDD:212012
		HR1_PKN1_2	126..197	CDD:212020
		HR1	214..286	CDD:294066
		C2_PKN-like	397..484	CDD:176069	5/29 (17%)
		STKc_PKN	624..948	CDD:270741	148/325 (46%)
		S_TKc	624..883	CDD:214567	122/259 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840