Protein Alignment inaC and LATS2

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 146/538 - (27%)
• Similarity: 235/538 - (43%)
• Gaps: 124/538 - (23%)

  Fly   238 DRSGRTKKKTKT----IQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSL 298
            |:.|:.||:.:|    ::||              .:|.:||        :...::....:|.|.:
Human   566 DKGGKDKKQIQTSPVPVRKN--------------SRDEEKR--------ESRIKSYSPYAFKFFM 608

  Fly   299 EELQKEPVDGWYKFLS---QVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNM 360
            |:..:..:..:.:.::   |:|.|.......:|              .:...::.:..|:..:|.
Human   609 EQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEA--------------EQEQMRKILYQKESNYNR 659

  Fly   361 SKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILAL 425
            .||..:..:.|..:|.:|.|:||:|.||.:..|..|||:|.|||..::..:.:.....|:.|||.
Human   660 LKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAE 724

  Fly   426 SGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERD 490
            :.. .::|.::..||..|.|:|||:|..|||:|..:.:...|.|.:|.||..|:.:|:..:|:..
Human   725 ADN-EWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMG 788

  Fly   491 IIYRDLKLDNILLDGEGHVKLVDFGLS------------KEGVTERQTT---------------- 527
            .|:||:|.||||:|.:||:||.||||.            ::|...||.:
Human   789 FIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCG 853

  Fly   528 -------------------RTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGD 573
                               .:..|||||:|||::....|:...||||.||:|||.:.||.||...
Human   854 DRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAP 918

  Fly   574 DET-TVFRNIKDKKAV-FPKH--FSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDW 634
            ..| |..:.|..:..: .|..  .|.||.|:||. |....::||  ||....::..||||..:|:
Human   919 TPTETQLKVINWENTLHIPAQVKLSPEARDLITK-LCCSADHRL--GRNGADDLKAHPFFSAIDF 980

  Fly   635 DKAEACEMEPPIKPMIKHRKDISNFD------------DAFTKEKTDLT-PTDK---------LF 677
             .::..:...|..|.|.|..|.||||            :..||....|| |.:|         .|
Human   981 -SSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTF 1044

  Fly   678 MMNLDQNDFIGFSFMNPE 695
            ....|.|   |:.|..|:
Human  1045 RRFFDDN---GYPFRCPK 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342
		C1	137..190	CDD:412127
		C2_PKC_alpha_gamma	194..324	CDD:175992	16/92 (17%)
		STKc_PKC	375..692	CDD:270722	122/389 (31%)
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581
		PHA03247	<143..521	CDD:223021
		MobB_LATS2	587..669	CDD:439272	14/103 (14%)
		STKc_LATS2	668..1048	CDD:173715	120/384 (31%)