DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and pck1

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_593737.2	Gene:	pck1 / 2542293	PomBaseID:	SPAC17G8.14c	Length:	988	Species:	Schizosaccharomyces pombe

Alignment Length:	648	Identity:	208/648 - (32%)
Similarity:	317/648 - (48%)	Gaps:	74/648 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RKGAMKRKGLEMVN---GHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVV 118
            |:||:::|..::|.   ||:|..|.|.....|..|.: ::.: ..|.|||.|.|..|:||...|:
pombe   396 RQGAIRQKKEDVVASQVGHQFVQRQFYQIMRCAVCAE-LFSY-SPGLQCENCSFVCHKKCVTKVL 458

  Fly   119 FKC----PGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQ 179
            ..|    ..:.:||.....::.|.:.........:|..||..|........||..|.:..|..|.
pombe   459 ASCIAQSNSEKSDFGGLRYRIPHRFEPFNSLGAQWCAHCGFFLPLRRKDCFKCVECGITCHGQCA 523

  Fly   180 ETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTK 244
            ..:|..||.. ::::.:||..:|:.....|.::....|   ..||.      .|...|..|..|.
pombe   524 HLIPDYCGMS-NDLKHQLLTELEVSKRPKKPELPNQEN---KTTNE------KVYRKPLSSQNTF 578

  Fly   245 KKTKTIQKNL----NPVFNETFTFEL-QPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKE 304
            ....||.:.|    .||.:...|..| :..::|:.|.:.......|..:......|.||...:
pombe   579 DTLPTISQGLLAATQPVTSVLNTSPLPKTPEKDRSLNVTPSSSTPTPASVLAPPSSASLSSSK-- 641

  Fly   305 PVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMIRAA 369
                                  ||...:            |...||          .|::.:...
pombe   642 ----------------------DANRSV------------PESPRR----------EKKNRVTLD 662

  Fly   370 DFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRP--PFL 432
            ||.|:.|:|||:||||:|||.:...:.||:|||:|:.|::.:::|....||.:..::.:.  |||
pombe   663 DFTFLAVLGKGNFGKVMLAEYKVNKKFYAIKVLKKEAILKNEELESLKTEKHVFEVANKEKHPFL 727

  Fly   433 VSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLK 497
            :::.:.|||..|::|||||..|||||.|:|:. :|....|.||..||.:||.:.||..|.|||||
pombe   728 LNLFASFQTSTRVYFVMEYILGGDLMVHIQRQ-QFSVKRARFYGAEVCLALKYFHENGIAYRDLK 791

  Fly   498 LDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFE 562
            ||||||..:||:::.|:||.||.:....||.||||||.:|||||:....||...|||:||||:::
pombe   792 LDNILLCPDGHIRIADYGLCKENMLLGNTTSTFCGTPEFMAPEILLEQQYSKDVDWWAFGVLMYQ 856

  Fly   563 FMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHP 627
            .:.||:||:|:||..:|..|...:.:||.:...:|:.::...||:.||.|||:|.....|:..||
pombe   857 MLLGQSPFKGEDEEEIFDAILSDEPLFPINMPADAVSLLRGLLTRDPNQRLGSGPKDANEVMAHP 921

  Fly   628 FFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFS 690
            ||.::.||.......||..||:|...:|::|||:.||.....|||.:.: :....|..|.|||
pombe   922 FFASIVWDDLYNKLYEPSYKPLINDPRDLNNFDEEFTSACPTLTPVNTV-LTRQQQECFRGFS 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	17/55 (31%)
		C1_1	137..189	CDD:278556	13/51 (25%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	24/134 (18%)
		S_TKc	371..629	CDD:214567	116/259 (45%)
		STKc_PKC	375..692	CDD:270722	137/318 (43%)
pck1	NP_593737.2	HR1_PKC-like_1_fungi	2..73	CDD:212011
		HR1	111..180	CDD:294066
		C2	212..316	CDD:301316
		C1_1	414..462	CDD:278556	16/49 (33%)
		C1_1	481..533	CDD:278556	13/51 (25%)
		S_TKc	664..923	CDD:214567	116/259 (45%)
		STKc_PKC	668..983	CDD:270722	135/316 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	46	1.000	Domainoid score	I3535
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	437	1.000	Inparanoid score	I315
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060