DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and pck2

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_595950.1	Gene:	pck2 / 2539649	PomBaseID:	SPBC12D12.04c	Length:	1016	Species:	Schizosaccharomyces pombe

Alignment Length:	723	Identity:	230/723 - (31%)
Similarity:	349/723 - (48%)	Gaps:	115/723 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PSAAPGAKAPAAGAGKGPGNLLEITGEANI-VNYMKNRLRKGAM------------KRKGLEMVN 70
            |:.|.|.::.:|...      ||..|:.|: :|:.|:..||..|            :::.:..|.
pombe   346 PNTASGNQSVSAWFS------LEPMGQINLTMNFTKHNTRKRPMDAGLGRQGAIRQRKESVHEVY 404

  Fly    71 GHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTD-----FDA 130
            ||:|....|.....|..|.:|:  ....|.||.:|.:..|:||...||.||..|.:|     ::.
pombe   405 GHKFLQHQFYQIMRCALCGEFL--KNAAGMQCIDCHYTCHKKCYPKVVTKCISKSSDSASSEYEK 467

  Fly   131 DCAKVKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGAD------ 189
            ...::.|.:.|.|.....:|..||.:|........||..|.:..|..|...||..||..
pombe   468 INHRIPHHFESHTNIGANWCCHCGYILPLGRKTARKCTECGITAHAQCVHLVPDFCGMSMEMANR 532

  Fly   190 -ISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTK----KKTKT 249
             |||:|                                :......|.|..:|...|    ||:|:
pombe   533 VISEIR--------------------------------TTKIYKAQQHKQKSSHHKHHHHKKSKS 565

  Fly   250 IQK------NLNPVFNETFTFELQPQD----RDKRLLIE--------VWDWDRTSRND-FMGSFS 295
            ...      ..:.....|.|..:.|.|    ..|.|.||        ..:.:.||.:| .:|:..
pombe   566 SSSKHKENDKASVSITTTTTPSITPADPVPTSPKPLAIEPVKRKPVHAGNLEVTSVSDNKLGATV 630

  Fly   296 FSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNM 360
            ..:|:...:..|...|           .|.:||..:...:         |:.:..:..:|:.|
pombe   631 QVVEQKVDDKADALTK-----------PPSLDAVKEPIPV---------PSVETSVVAQDLTH-- 673

  Fly   361 SKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILAL 425
             |...|...||.|:.|:|||:||||:|||.:...:|||:|||:|:.|::.|::|...:||::..:
pombe   674 -KAKRIGLEDFTFLSVLGKGNFGKVMLAELKSEKQLYAIKVLKKEFILENDEVESTKSEKRVFLV 737

  Fly   426 SGRP--PFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHE 488
            :.|.  ||||::||||||..|::|||::..|||||.|:|| .:|....|.|||.||.:||.:.|:
pombe   738 ANRERHPFLVNLHSCFQTETRIYFVMDFVSGGDLMLHIQQ-EQFSRRRAQFYAAEVCLALKYFHD 801

  Fly   489 RDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADW 553
            ..|||||||||||||..:||||:.|:||.||.:....||.||||||.:|||||:....|:.:.||
pombe   802 NGIIYRDLKLDNILLSPDGHVKVADYGLCKEDMWHDNTTATFCGTPEFMAPEILLEQQYTRSVDW 866

  Fly   554 WSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRY 618
            |:||||:::.:.||:||.|:||..:|..|...:.::|.|...:::.|:...||:.|..|||:|..
pombe   867 WAFGVLIYQMLLGQSPFRGEDEEEIFDAILSDEPLYPIHMPRDSVSILQQLLTRDPKKRLGSGPN 931

  Fly   619 ARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQ 683
            ..:::.|||||.|::||.......:||..|.:....|...||:.||:|...|||.:.:....:.|
pombe   932 DAEDVMTHPFFSNINWDDIYHKRTQPPYIPSLNSPTDTKYFDEEFTRELPVLTPVNSILTKEMQQ 996

  Fly   684 NDFIGFSF 691
            : |.|||:
pombe   997 H-FEGFSY 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	17/51 (33%)
		C1_1	137..189	CDD:278556	16/51 (31%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	23/152 (15%)
		S_TKc	371..629	CDD:214567	123/259 (47%)
		STKc_PKC	375..692	CDD:270722	143/319 (45%)
pck2	NP_595950.1	HR1_PKC-like_1_fungi	2..73	CDD:212011
		HR1_PKC-like_2_fungi	115..186	CDD:212010
		C2_fungal_Pkc1p	213..320	CDD:176071
		C1_1	406..454	CDD:278556	16/49 (33%)
		C1_1	474..526	CDD:278556	16/51 (31%)
		S_TKc	683..942	CDD:214567	123/259 (47%)
		STKc_PKC	688..1003	CDD:270722	142/316 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	46	1.000	Domainoid score	I3535
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	437	1.000	Inparanoid score	I315
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060