DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and Prkcb

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_036845.3	Gene:	Prkcb / 25023	RGDID:	3396	Length:	673	Species:	Rattus norvegicus

Alignment Length:	682	Identity:	346/682 - (50%)
Similarity:	462/682 - (67%)	Gaps:	30/682 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFI 92
            ||||....       .||.:.|.:    .||||:::|.:..|..|:|..||||.||:|.||.|||
  Rat     4 PAAGPPPS-------EGEESTVRF----ARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFI 57

  Fly    93 WGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLL 157
            ||.|.||||.:.|.|.:|::|.:||.|.|||.|....:|..:.||.:...||::|||||.||.||
  Rat    58 WGLGLQGFQSQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLL 122

  Fly   158 HGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMD 222
            :|:.|||:||:.|.:|||..|...||.:||.|.:|.||::.:...:....|.|.:::|.||:|||
  Rat   123 YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMD 187

  Fly   223 TNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSR 287
            .||.||||:.:::.||....:|:|||||:.:|||.:||||.|:|:..|:|:||.:|:||||.|||
  Rat   188 PNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSR 252

  Fly   288 NDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPC-VDAFNDIARLRDEVRH------DRRP 345
            ||||||.||.:.||||..||||:|.|||.|||::|:|. .:.......||.:...      .:.|
  Rat   253 NDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAP 317

  Fly   346 NEK-----RRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKD 405
            .||     .:.||.      ..||.::..||||:.|:||||||||:|:||:|||||||||:|:||
  Rat   318 EEKTANTISKFDNN------GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 376

  Fly   406 VIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKES 470
            |:||.||:|..|.||::|||.|:||||..:||||||||||:|||||..|||||||:||.|||||.
  Rat   377 VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP 441

  Fly   471 VAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPN 535
            .|:|||.|:||.||||..:.||||||||||::||.|||:|:.|||:.||.:.:..||:||||||:
  Rat   442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD 506

  Fly   536 YMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDI 600
            |:||||::|.||..:.|||:|||||:|.:||||||||:||..:|::|.:....:||..|.||:.|
  Rat   507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571

  Fly   601 ITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTK 665
            ....:||.|..|||.|....::|..|.|||.:||:|.|..|::||.||....| :..|||..||:
  Rat   572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFTR 635

  Fly   666 EKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFI 697
            ....|||.|:..:.|:||::|.||||:|.||:
  Rat   636 HPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFL 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	30/51 (59%)
		C1_1	137..189	CDD:278556	27/51 (53%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	69/129 (53%)
		S_TKc	371..629	CDD:214567	157/257 (61%)
		STKc_PKC	375..692	CDD:270722	183/316 (58%)
Prkcb	NP_036845.3	C1_1	37..89	CDD:278556	30/51 (59%)
		C1_1	102..152	CDD:278556	25/49 (51%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	69/129 (53%)
		STKc_cPKC_beta	341..663	CDD:270767	188/322 (58%)
		S_TKc	342..600	CDD:214567	157/257 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343108
Domainoid	1	1.000	63	1.000	Domainoid score	I10001
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103255
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750