DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and Akt1

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_150233.1	Gene:	Akt1 / 24185	RGDID:	2081	Length:	480	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	145/441 - (32%)
Similarity:	236/441 - (53%)	Gaps:	34/441 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 KKKTKTIQKNLNPVFN-ETFTFELQPQDRDK--RLLIEVWDW----DRTSRNDFMGSFSFSLEEL 301
            |::.:.:::..:|:.| .....:|...:|.:  ..:|....|    :||        |.....|.
  Rat    39 KERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERT--------FHVETPEE 95

  Fly   302 QKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSK-RDM 365
            ::|    |...:..|.            :.:.|..:|....|..:.......::|...::| :..
  Rat    96 REE----WTTAIQTVA------------DGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHR 144

  Fly   366 IRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPP 430
            :...:|.::|::|||:||||:|.:.:.|...||:|:|:|:||:..|::...:.|.::|. :.|.|
  Rat   145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHP 208

  Fly   431 FLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLH-ERDIIYR 494
            ||.::...|||.|||.|||||..||:|.:|:.:...|.|..|.||..|:..||.:|| |::::||
  Rat   209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYR 273

  Fly   495 DLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVL 559
            ||||:|::||.:||:|:.||||.|||:.:..|.:||||||.|:|||::..:.|..|.|||..||:
  Rat   274 DLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVV 338

  Fly   560 LFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEIT 624
            ::|.|.|:.||...|...:|..|..::..||:....||..:::..|.|.|..|||.|....:||.
  Rat   339 MYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIM 403

  Fly   625 THPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDK 675
            .|.||.|:.|......::.||.||.:....|...||:.||.:...:||.|:
  Rat   404 QHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQ 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992	14/86 (16%)
		S_TKc	371..629	CDD:214567	110/258 (43%)
		STKc_PKC	375..692	CDD:270722	125/302 (41%)
Akt1	NP_150233.1	PH_PKB	4..111	CDD:269947	14/95 (15%)
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	14..19
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	23..25
		STKc_PKB_alpha	124..479	CDD:270746	128/332 (39%)
		Inhibitor binding. /evidence=ECO:0000250	228..230		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..480		2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920