Protein Alignment inaC and SGK3

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_037389.4
• Gene: SGK3 / 23678
• HGNCID: 10812
• Length: 496
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 181/523 - (34%)
• Similarity: 261/523 - (49%)
• Gaps: 77/523 - (14%)

  Fly   210 VDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPV-FNETFTFELQPQ-DR- 271
            :|.||            |.|.:::....:.  |.|||..|:.|.|..| .:|.|.|....: |:
Human     7 MDYKE------------SCPSVSIPSSDEH--REKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKL 57

  Fly   272 ----------------DKRLLIEVWDWD-----RTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQ 315
                            .||:..:.:|.|     |...|:|       ::.|.:.|
Human    58 YNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEF-------IQNLVRYP---------- 105

  Fly   316 VEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMI--------RAADFN 372
               |.||.|.|.||..:    |..:|...|:|.....:....|:.|:...:        :..||:
Human   106 ---ELYNHPDVRAFLQM----DSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFD 163

  Fly   373 FVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHS 437
            |:||||||||||||||:|:...:.||||||:|.:::...:.:..|.|:.:|..:.:.||||.:|.
Human   164 FLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228

  Fly   438 CFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNIL 502
            .|||.::|:||:::..||:|.:|:|:...|.|..|.|||.|:|.||.:||...|:|||||.:|||
Human   229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENIL 293

  Fly   503 LDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQ 567
            ||..|||.|.||||.|||:....||.||||||.|:|||::...||....|||..|.:|:|.:.|.
Human   294 LDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGL 358

  Fly   568 APFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNV 632
            .||...|...::.||..|........|:.|..|:...|.|...||||| :....||..||||.::
Human   359 PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPFFESL 422

  Fly   633 DWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKT--DLTPTDKLFMMN---LDQND-FIGFSF 691
            .|......::.||..|.:....||.|||.|||:|..  .:..:....::|   |:.:| |:|||:
Human   423 SWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSY 487

  Fly   692 MNP 694
            ..|
Human   488 APP 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342
		C1	137..190	CDD:412127
		C2_PKC_alpha_gamma	194..324	CDD:175992	29/137 (21%)
		STKc_PKC	375..692	CDD:270722	138/322 (43%)
SGK3	NP_037389.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		5/25 (20%)
		PX_CISK	12..120	CDD:132780	30/133 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..156		5/34 (15%)
		STKc_SGK3	165..490	CDD:270755	138/325 (42%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		1/9 (11%)